ISNS2018

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ISNS October11-13Tokyo Garden Terrace Kioicho Kioi Conference President:Yuko Kitagawa
Congress Secretariat

c/o Japan Convention Services, Inc.
14F. Daido Seimei Kasumigaseki Bldg.
1-4-2 Kasumigaseki Chiyoda-ku Tokyo
100-0013 Japan
Tel: +81-3-3508-1214
Fax: +81-3-3508-1302
Email: isns2018[A]convention[D]co[D]jp ( Please change[A] to @, [D] to . )

Scientific Program

Program at a Glance

October 11 Thu October 12 Fri October 13 Sat

(As of September 25, 2018)

Keynote Lecture

Keynote Lecture 1

Chair: Masaki Kitajima (International University of Health and Welfare, Japan)
Speaker: THE FUTURE OF THE ISNS: LOOKING FORWARD TO THE YEAR 2020
Charles M. Balch (Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, USA)

Keynote Lecture 2: Presidential Lecture

Chair: Alessandro A.E. Testori (Chairman of Surgery, EORTC Melanoma Group, Italy)
Speaker: Unlimited potential of sentinel node concept in solid tumor oncology
Yuko Kitagawa (Department of Surgery, Graduate School of Medicine, Keio University, Japan)

Keynote Lecture 3

Chair: Takashi Aikou (Seiunkai Hospital, Japan)
Speaker: The History of the International Sentinel Node Society
John F. Thompson (Melanoma and Surgical Oncology, Melanoma Institute Australia, The University of Sydney, Australia)

Future Prospects

Chairs: Tadashi Ikeda (Breast Center, Kitasato University Kitasato Institute Hospital, Japan)
Jeffrey E. Gershenwald (Surgical Oncology, MD Anderson Cancer Center, USA)
Speakers: Current problems and future perspective of sentinel lymph node biopsy in breast cancer
Hiromitsu Jinno (Department of Surgery, Teikyo University School of Medicine, Japan)
Melanoma: Future Prospects in Lymphatic Mapping
Mark B. Faries (Surgical Oncology, The Angeles Clinic and Research Institute / Cedars Sinai Medical Center, USA)
Evaluation of Sentinel Lymph Node Mapping in Colon Cancer and Future Perspective and Paradigm Shift
Sukamal Saha (MSU College of Human Medicine, USA / Mclaren Flint, USA)
Future prospects of SNNS in upper gastrointestinal cancer
Hiroya Takeuchi (Department of Surgery, Hamamatsu University School of Medicine, Japan)
The use of sentinel node biopsy and novel molecular approaches to improve triage in high risk cutaneous SCC of the head and neck.
Richard C.W. Martin (Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Australia / Melanoma Unit, Waitemata Health and Auckland Regional Head and Neck Service, University of Auckland, New Zealand)
Future of navigation surgery for cervical cancer
Fabrice Lecuru (Gynecologic and Breast Oncology Department, Georges Pompidou European Hospital, APHP, France / Faculté de Médecine, Paris Descartes University, France)

Plenary Session

Plenary Session 1

Chair: John F. Thompson (Melanoma and Surgical Oncology, Melanoma Institute Australia, The University of Sydney, Australia)
Speaker: Prediction of Outcome from the Amount and Distribution of Melanoma in Sentinel Nodes
Alistair John Cochran (Pathology and Surgery, UCLA David Geffen School of Medicine, USA)

Plenary Session 2

Chair: Hirofumi Fujii (Division of Functional Imaging, National Cancer Center, Japan)
Speaker: Pre-Operative Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Melanoma and Breast Cancer
Roger F. Uren (Sydney Medical School, University of Sydney and Melanoma Institute Australia / Alfred Nuclear Medicine and Ultrasound, Australia)

Plenary Session 3

Chair: Corrado Caracò (Division of Surgery of Melanoma and skin cancer, Istituto Nazionale Tumori "Fondazione Pascale", Italy)
Speaker: Cancer Metastasis: A Complicated Journey from the Primary Site to the Sentinel Lymph Nodes and Beyond in Relationship to the Immune System
Stanley P. Leong (Department of Surgery and Melanoma Center, California Pacific Medical Center, USA)

Symposium

Symposium 1

Axillary management in different molecular subtypes in breast cancer patients with sentinel node macrometastasis

Chairs: Hiroyuki Takei (Department of Breast Surgery, Nippon Medical School, Japan)
Monica Rizzo (Department of Surgery, Division of Surgical Oncology, Emory University School of Medicine, USA)
Keynote Lecture: Spatial heterogeneity revealed by genomic profiles comparing 60 matched primary breast tumors and metastatic lymph nodes Background
Ning Liao (Department of Breast Cancer, Guangdong General Hospital & Guangdong Academy of Medical Sciences, China)
Speakers: Modern Management of the Axilla in Breast Cancer
Monica Rizzo (Department of Surgery, Division of Surgical Oncology, Emory University School of Medicine, USA)
Phase II study on feasibility of sentinel lymph node biopsy for ycN0 patients treated with primary chemotherapy in cT1-3N1M0 breast cancer: SHARE study on behalf of investigators at the Japanese Society for Sentinel Node Navigation Surgery
Shigeru Imoto (Department of Breast Surgery, Kyorin University School of Medicine, Japan)
Metastatic prediction with non-sentinel lymph node by SLN ratio
Yuko Kawai (Department of Surgery, School of Medicine, Keio University, Japan)
PREDICTION OF METASTASIS TO NON-SENTINEL LYMPH NODES METASTASES FROM DYNAMIC STATUS OF 18F-FLUORO-DEOXYGLUCOSE EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY IMAGES FINDINGS OF PRIMARY BREAST CANCERS
Yoji Yamagishi (Department of Basic Pathology, National Defense Medical College, Japan / Department of Surgery, National Defense Medical College, Japan)
Study on the validity of sentinel lymph node biopsy after preoperative chemotherapy
Akira Matsui (Department of Breast Surgery, National Hospital Organization Tokyo Medical Center, Japan)
The loss of lymph node metastasis after neoadjuvant chemotherapy in patients with cytology-proven node-positive primary breast cancer
Maki Namura (Department of Breast Surgical Oncology, St Luke's International Hospital, Japan)
Retrospective study of axillary management after preoperative chemotherapy amongst breast cancer patients in our institute
Mizuho Tazo (St. Marianna University School of Medicine, Japan)
The prognostic value of micrometastasis of sentinel lymph nodes in breast cancer
Hiromi Miyamoto (Department of Breast Surgery, Tokyo Metropolitan Komagome Hospital, Japan)

Symposium 2

Advances in treatment for gastrointestinal cancer based on sentinel node biopsy

Chairs: Markus Zuber (Kantonsspital Olten, Switzerland)
Sukamal Saha (MSU College of Human Medicine, USA / Mclaren Flint, USA)
Speakers: Risk factors for lymph node metastasis in non-sentinel node basins in early gastric cancer
Masashi Takeuchi (Department of Surgery, Keio University School of Medicine, Japan)
Staging of node negative colon cancer significantly improves with sentinel lymph node mapping
Benjamin Weixler (Department of Surgery, Charité University Hospital, Germany / Department of Surgery, Kantonsspital Olten, Switzerland)
META-ANALYSIS OF SKIP METASTASIS AFTER SENTINEL LYMPH NODE MAPPING IN GASTROINTESTINAL CANCERS AND ITS BIOLOGICAL RELEVANCE: AN INTERNATIONAL DATA
Sukamal Saha (MSU College of Human Medicine, USA / McLaren Flint, USA)
Lymphatic flow of patients with gastric cancer with pM/SM1 and no lymphovascular invasion; Sentinel node concept
Masashi Takeuchi (Department of Surgery, Keio University School of Medicine, Japan)
VALIDATION OF LYMPHATIC MAPPING IN COLON CANCER : AN INTERNATIONAL STUDY OF > 5000 PATIENT'S DATA FROM 3 CONTINENTS
Sukamal Saha (MSU College of Human Medicine, USA / McLaren Flint, USA)
Clinical outcomes of sentinel node navigated surgery by indocyanine green (ICG) plus infrared ray laparoscopic system (IRLS) for early gastric cancer (EGC)
Naoto Takahashi (Department of Surgery, The Jikei Kashiwa University Hospital, Japan)
Sentinel node mapping by indocyanine green fluorescence imaging and metastatic diagnosis by one-step nucleic acid amplification in laparoscopic gastric cancer surgery
Yoshiaki Shoji (Department of Gastroenterological Surgery, The Cancer Institute Hospital of JFCR, Japan)
Image based fusion SPECT/CT for pre-operative evaluation of sentinel node in esophageal cancer; comparative study of Tc-99m neomannosyl human serum albumin versus Tc-99m phytate
Hyun Koo Kim (Department of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, Korea)

Symposium 3

Basic research of sentinel lymph node and its-related lymph circulation

Chairs: Dave SB Hoon (Translational Molecular Medicine, John Wayne Cancer Institute, Providence Health System, USA)
Toshio Ohhashi (Department of Innovation of Medical and Health Sciences Research, Shinsyu University School of Medicine, Japan)
Speakers: Physiological research of sentinel lymph node with lymph flow dynamics and its clinical application
Yoshiko Kawai (Department of Physiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan / Department of Innovation of Medical and Health Sciences Research, Shinshu University School of Medicine, Japan)
Roles of TGF-β family signals in the formation and maintenance of lymphatic systems
Tetsurou Watabe (Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan)
A PAN-TUMOR FLUORESCENT IMAGING PROBE THAT DETECTS PRIMARY CANCER AND LYMPH NODE METASTASES
Charles M. Balch (The University of Texas MD Anderson Cancer Center, USA)
Basic and clinical researches in upper GI sentinel node assessment
Hiroya Takeuchi (Department of Surgery, Hamamatsu University School of Medicine, Japan)
From basic research to clinical application of sentinel node concept in gastric cancer
Shoji Natsugoe (Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medical, Japan)

Symposium 4

Visualization of sentinel lymph nodes and allied vasculature

Chairs: Hirofumi Fujii (Division of Functional Imaging, National Cancer Center, Japan)
Roger F. Uren (Sydney Medical School, University of Sydney and Melanoma Institute Australia / Alfred Nuclear Medicine and Ultrasound, Australia)
Introduction: Roger F. Uren (Sydney Medical School, University of Sydney and Melanoma Institute Australia / Alfred Nuclear Medicine and Ultrasound, Australia)
Speakers: ICG fluorescence-guided Sentinel node Navigation Surgery for Head and Neck Squamous Cell Carcinoma Patients
Takehiro Nakamura (Department of Otolaryngology, Kosei Hospital, Japan)
Sentinel lymph node mapping based on magnetic force in non-small cell lung cancer
Kazuhiro Imai (Thoracic Surgery, Akita University Graduate School of Medicine, Japan)
Re-operative sentinel lymph node biopsy for ipsilateral breast tumor recurrence: impact of axillary surgery and radiotherapy on lymphatic drainage patterns
Ayaka Sato (Department of Breast Surgical Oncology, Breast Oncology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Japan / Department of Breast and Endocrine Surgery, The University of Tokyo Hospital, Japan)
Impact of Aberrant Sentinel Lymph Node Drainage in Melanoma
Patients from a Multicenter International Trial
Trang Nguyen (Department of Surgical Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, USA)

Symposium 5

Utilization of a non-radioisotopic tracer in sentinel node biopsy of head and neck, and urologic cancers

Chairs: Sandro J. Stoeckli (Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Switzerland)
Yasuhisa Hasegawa (Asahi University Hospital, Japan)
Speakers: The multicenter feasibility study of novel minimally invasive strategy combination with transoral surgery and ICG fluorescence-navigated sentinel node biopsy in laryngopharyngeal cancer
Masayuki Tomifuji (Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Japan)
A magnetic sentinel node procedure for oral cancer patients
Eliane R. Nieuwenhuis (Magnetic Detection & Imaging, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Netherlands)
Detection of sentinel node using contrast-enhanced agent, SonazoidTM, and evaluation of its metastasis with Superb Microvascular Imaging in oral and oropharyngeal cancers: A preliminary clinical study
Naohiro Wakisaka (Department of Otolaryngology, and Head & Neck Surgery, Kanazawa University, Japan)
Sentinel node biopsy in prostate and bladder cancer using magnetic nanoparticles and a new magnetic detection technique
Lennert Molenaar (Magnetic Detection & Imaging, Faculty Science and Technology, University of Twente, Netherlands)

Symposium 6

Management and treatment of sentinel-node metastasis in melanoma

Chairs: Corrado Caracò (Division of Surgery of Melanoma and Skin Cancer, Istituto Nazionale Tumori "Fondazione Pascale", Italy)
Naoya Yamazaki (Department of Dermatologic Oncology, National Cancer Center Hospital, Japan)
Keynote Lectures: Management of melanoma patients with a sentinel-node metastasis
Omgo E. Nieweg (Melanoma Institute Australia / The university of Sydney / Royal Prince Alfred Hospital, Australia)
The natural history of melanoma patients with positive sentinel node who do not undergo immediate completion lymph node dissection
Daniel Coit (Department of Surgery, Memorial Sloan Kettering Cancer Center, USA)
Speakers: Utility of Genetic and Epigenetic Blood Cell-Free DNA(cfDNA) Biomarkers in Management of Melanoma Patients with Regional Lymph Node Metastasis
Dave SB Hoon (Department of Translational Molecular Medicine, John Wayne Cancer Institute, Providence Health System, USA)
Risk stratification of Sentinel Node Positive Melanoma Patients May Define Indications for Completion Lymph Node Dissection
Andrea Maurichi (Melanoma and Sarcoma Surgical Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy)
Management and Prognostic Significance of Tumour-positive Triangular Intermuscular Space Sentinel Nodes in Patients with Melanoma
Trine Schoenfeldt (Melanoma Institute Australia, Australia)
Accuracy of lymphatic mapping after previous wide local excision in primary cutaneous melanoma
Annabelle Teng (Surgical Oncology, John Wayne Cancer Institute, Providence St. John's Health Center, USA)
Location of malignant melanoma in distal lower extremity draining to popliteal sentinel lymph nodes
Shunichi Jinnai (Department of Dermatologic Oncology, National Cancer Center Hospital, Japan)
Correlation of tumor burden parameters between sentinel and non-sentinel lymph nodes in patients with cutaneous melanoma
Kenjiro Namikawa (Department of Pathology, The University of Texas MD Anderson Cancer Center, USA / Department of Dermatologic Oncology, National Cancer Center Hospital, Japan)
Do the Results of the Completion Lymph Dissection Trials Diminition the Clinical relevance of SLN biopsy?
Merrick Ross (Department of Surgical Oncology, MD Anderson Cancer Center)

Symposium 7

SNNS in gynecological cancers

Chairs: Nobuyuki Susumu (International University of Health and Welfare, Mita Hospital, Japan)
Hitoshi Niikura (National Hospital Organization Sendai Medical Center)
Speakers: Unexpected lymphatic drainage pathways of cervical cancer: Is it possible to predict them?
Vincent Balaya (Department of Gynecologic and Breast Oncologic Surgery, Georges Pompidou European Hospital, France)
Evaluation of effectiveness in sentinel node navigation surgery to high-risk endometrial cancer patients by cervical injection method
Asami Toki (Department of Obstatrics and Gynecology, Tohoku University Hospital, Japan)
Comparison of sentinel node mapping using between dye and fluorescence methods in patients with endometrial cancer
Michiko Wada (Department of Obstatrics and Gynecology, Keio University School of Medicine, Japan / Division of Obstetrics and Gynecology, National Hospital Organization Saitama National Hospital, Japan)
Endometrial carcinomas: lymph node staging with SND by retroperitoneal laparoscopic approach
Frederic Guyon (Department of Surgery, Institut Bergonié Comprehensive Cancer Center, France)

Symposium 8

New technology and Ongoing clinical trial

Chairs: Shoji Natsugoe (Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medical, Japan)
Keun Won Ryu (Center for Gastric Cancer, National Cancer Center, Korea)
Speakers: New technology and ongoing clinical trials for SN mapping in gastric cancer
Hiroya Takeuchi (Department of Surgery, Hamamatsu University School of Medicine, Japan)
Results of interim analysis of the multicenter randomized phase III SENORITA trial of laparoscopic sentinel node oriented stomach-preserving surgery versus laparoscopic standard gastrectomy with radical lymph node dissection in early gastric cancer
Keun Won Ryu (Center for Gastric Cancer, National Cancer Center, Korea)
Feasibility of combining super paramagnetic iron oxide with a magnetometer as a novel single tracer method of sentinel lymph node navigation surgery for gastric cancer in a swine experimental model
En Amada (Department of Surgery, Keio University School of Medicine, Japan)
Next-generation sequencing of the dominant primary lesion and sites of lymph node metastases may help guide sentinel lymph node efforts for pelvic lymphadenectomy in prostate cancer
Ramkishen Narayanan (Department of Urologic Oncology, John Wayne Cancer Institute, USA)
Association of preoperative magnetic resonance imaging (MRI) with crossover of lymph node invasion in prostate cancer: important to keep in mind for sentinel node based prostate cancer pelvic lymphadenectomy
Ramkishen Narayanan (Department of Urologic Oncology, John Wayne Cancer Institute, USA)
Comparison between 99mTc-Neomannosyl Human Serum Albumin (99mTc-MSA) and 99mTc-Phytate for Sentinel Node Identification in Lung Cancer
Hyun Koo Kim (Department of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, Korea)

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