Patients with severe aortic stenosis often exhibit sometimes gastrointestinal bleeding due to hemostatic disorder caused by excess cleavage of von Willebrand factors, critical hemostatic factors. This cleavage is more prominent in PCPS and LVAD and it is often difficult to control bleeding in patients with such mechanical circulatory support. Aortic aneurysm sometimes causes chronic and high-grade DIC. Until what degree of thrombocytopenia, can we perform PCI safely? Do you have experience that you are surprised at noticing severe thrombocytopenia during treatment of ACS patients with heparin? This could be due to heparin-induced thrombocytopenia, HIT. Some physicians consider that antiplatelet therapy should be perform only for embolism-very-high-risk patients with atrial fibrillation undergoing chronic hemodialysis since hemodialysis is a risk for bleeding. Thus, we treat many cardiovascular patients accompanied with hemostatic disorder/bleeding tendency in clinical settings. In this symposium, we would discuss diagnosis and therapy for these patients from the points of cardiovascular medicine and hemostasis/thrombosis medicine, by recruiting abstracts widely from JSC members.