TakaoSymposium 2017

Scientific Program

Scientific Program

Oct 6th at Hotel Hakucho

17:00 Registration opens
17:55 Opening remarks

Hiroyuki Yamagishi

(Keio University School of Medicine)

18:00 – 18:30 Welcome Reception
18:30 – 18:50 Evening Seminar (Sponsored by AbbVie)
Moderators: Toshio Nakanishi

RS virus infection in children with heart and lung diseases

Hiroyuki Yamagishi

18:50 – 19:50 Evening Lecture (Sponsored by AbbVie)
Moderators: Shigetoyo Kogaki

Fundamental insight into pulmonary vascular disease: Perspectives from pediatric PAH

Yoshihide Mitani

(Mie University. Graduate School of Medicine/Faculty of Medicine)

– 21:00 Welcome Reception

Oct 7th at Kunibiki Messe

8:15 – 9:30 Session 1. Bridge over troubled heart I
Moderators: Osamu Nakagawa
Scott Baldwin

Session 1.1(8:15–8:45)

Quantification of contractility in stem cell derived cardiomyocyte

Konrad Brockmeier

(University Hospital of Cologne, Germany)

Session 1.2(8:45–9:15)

Mechanisms regulating second heart field progenitor cell deployment

Robert G. Kelly

(University of Aix-Marseilles, France)

Session 1.3(9:15–9:30)

Novel cardiac progenitors for all components of the heart except for the right ventricle

Hiroki Kokubo

(Hiroshima Univ., Graduate School of Biomedical & Health Sciences)

9:30 – 10:00 Break
10:00 – 11:30 Session 2. Bridge over troubled heart II
Moderators: Hiroki Kurihara
Adriana Gittenberger-de Groot

Session 2.1(10:00–10:30)

A molecular switch for cardiac differentiation control

Ivan P Moskowitz

(The University of Chicago, USA)

Session 2.2(10:30–11:00)

The endocardium as a master regulator of ventricular trabeculation

Scott H. Baldwin

(Vanderbilt University Medical Center, USA)

Session 2.3(11:00–11:30)

The role of alternative mRNA splicing in heart development

Douglas C. Bittel

(Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine)

11:30 – 12:20 Luncheon Seminar 1 (Sponsored by GlaxoSmithKline)
Moderators: Toshio Nakanishi

Pathophysiologic characteristics of pulmonary circulation in congenital heart disease

Hideaki Senzaki

(Div. of Pediatric Cardiology, Saitama Medical Center, Saitama Medical University)

12:20 – 14:00 Poster Session 1 (Presentation)
14:00 – 14:30 TAKAO Keynote Lecture
Moderators: Kenta Yashiro

Alternative cell fate selection and following directed cell migration coordinate epithelial pattern of branching airways

Mitsuru Morimoto

(RIKEN Center for Developmental Biology)

14:30 – 16:30 Session 3. Basic science of pulmonary hypertension
Moderators: Kyoko Imanaka-Yoshida
Robert G. Kelly

Session 3.1(14:30–15:00)

Smooth muscle cell progenitors and pulmonary hypertension

Daniel M. Greif

(Cardiovascular Medicine Yale Cardiovascular Research Center)

Session 3.2(15:00–15:30)

The mechanistic basis of prostacyclin action in pulmonary arterial hypertension: role of membrane versus nuclear receptors

Lucie Clapp

(Institute of Cardiovascular Science, UCL, UK)

Session 3.3(15:30–16:00)

Endothelial-to-mesenchymal transition in pulmonary hypertension

Frédéric Perros

(UMR-S 999 INSERM, Université Paris-Sud,, France)

Session 3.4(16:00–16:30)

Microvesicles, microRNAs and pulmonary hypertension

J. Usha Raj

(University of Illinois at Chicago, USA)

17:00 Viewing the sunset (17:44)
18:30 GALA Dinner at Matsue Vogel Park

Oct 8th at Kunibiki Messe

8:15 – 8:45 Morning Seminor
Moderators: Isao Shiraishi

Progress in the generation of multiple linease human-iPSC-derived 3D engineered cardiac tissues for cardiac repair

Bradley B. Keller

(University of Louisville, USA)

8:45 – 11:00 Session 4. Ductus arteriosus: a neighbor of the pulmonary artery
Moderators: Susumu Minamisawa
Lucie Clapp

Session 4.1(8:45–9:15)

Molecular, pharmacological, and genetic modulation of the ductus arteriosus

Elaine L. Shelton

(Vanderbilt University Medical Center, USA)

Session 4.2(9:15–9:45)

New mediators in the biology of the ductus arteriosus: Lessons from the chicken embryo

Eduardo Villamor

(Univ. Hospital Maastricht, The Netherlands)

Session 4.3(9:45–10:15)

Constriction of the ductus arteriosus with KATP channel inhibitors

Kazuo Momma

(Tokyo Women's Medical University)

Session 4.4(10:15–10:45)

The ductus arteriosus, a vascular outsider, in relation to the pulmonary circulation

Adriana Gittenberger-de Groot

(Leiden University Medical Center, The Netherlands)

Session 4.5(10:45–11:00)

New insights on how to treat patent ductus arteriosus

Utako Yokoyama

(Yokohama City University, Japan)

11:00 – 11:30 Break
11:30 – 12:30 TAKAO Memorial Lecture
Moderators: Hiroyuki Yamagishi

The Life of breath: Stem cell and the maintenance and repair of the adult lung

Brigid L. M. Hogan

(Duke University Medical Center, USA)

12:30 – 13:20 Luncheon Seminar 2 (Sponsored by Nippon-Shinyaku)
Moderators: Konrad Brockmeier

Development of novel therapies for pulmonary hypertension by clinical application of basic research

Kimio Satoh

(Dept. of Cardiovascular Medicine, Tohoku University Hospital, Japan)

13:20 – 14:30 Poster Session 2 (Free Discussion)
14:30 – 16:15 Session 5. Future promise of pulmonary hypertension therapy
Moderators: Yuichi Tamura
Brigid L. M. Hogan

Session 5.1(14:30–15:00)

Using patient-specific iPSCs to understand and treat pulmonary arterial hypertension

Mingxia Gu

(Stanford University School of Medicine, USA)

Session 5.2(15:00–15:30)

Modelling pulmonary arterial hypertension using induced Pluripotent stem cells

Amer A. Rana

(Department of Medicine, University of Cambridge, UK)

Session 5.3(15:30–16:00)

Dysfunction and restoration of endothelial cell communications in pulmonary hypertension: Therapeutic implications

Christophe Guignabert

(INSERM UMR S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.)

Session 5.4(16:00–16:15)

Inflammatory cytokines in the pathogenesis of pulmonary arterial hypertension

Yoshikazu Nakaoka

16:15 – 16:45 Break
16:45 – 18:15 Session 6. Clinical aspects of idiopathic pulmonary arterial hypertension in childhood
Moderators: Bradley B. Keller
Koichiro Tatsumi

Session 6.1(16:45–17:15)

Genotype to phenotype analysis in pediatric patients with idiopathic pulmonary arterial hypertension in China

Gu Hong

(Pediatric Cardiology, Beijing Anzhen Hospital, China)

Session 6.2(17:15–17:45)

Risk Stratification in children with pulmonary arterial hypertension

Shahin Moledina

(Great Ormond Street Hospital for Children, UK.)

Session 6.3(17:45–18:15)

The adaptive right ventricle in Eisenmengers: potential therapeutic targets for pulmonary hypertension?

Jeffrey R. Fineman

(Department of Pediatrics, University of California, USA)

18:15 – 18:20 Closing remarks

Toshio Nakanishi

(Tokyo Women's Medical University)

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