The 9th World Congress on Inflammation
Home Greeting Committees General Information Scientific Program Registration Call for Abstracts
Awards & Grants Sponsorships and Exhibition Social Program Hotel Reservation Excursion Affordable Japan Instruction for Participants
WCI 2009

TOKYO JAPAN

Scientific Program


:: Main Theme ::

Innovative Research of Inflammation, Repair and Regenerative Medicine.

:: Main Topics ::

  • * 6 Keynote Lectures
  • * 2 Special Lectures
  • * Main Morning Symposiums
    1. 1) Inflammation and Innate Immunity
    2. 2) Inflammation-associated Tissue Injury and Repair
    3. 3) New Strategies for Drug Discovery
    4. 4) Clinical Development of Novel Anti-Inflammatory Drugs
  • * IAIS Society-Sponsored Symposiums
  • * Workshops (invited lectures and presentations selected from posters)

Society-Sponsored Symposiums and Workshops will cover whole area of Inflammation Research (disease models, basic studies on inflammation and immunity, pharmacology and toxicology, inflammatory mediators, novel molecular targets, inflammatory diseases, cancer and inflammation, angiogenesis, drug discovery, novel therapeutics, and regenerative Medicine, etc.)

Programs

Opening Ceremony and Presidential Lecture
Keynote Lecture
Special Lecture
Morning Symposium
Workshop
Award Lectures
Society Sponsored Symposium
Industry Sponsored Symposium
Luncheon Seminar
Evening Seminar
Public Seminar


:: Timetable ::


Monday,July 6

Tuesday, July 7

Wednesday, July 8

Thursday, July 9

Friday, July 10


Opening Ceremony

Monday, July 6 16:30-17:00 Room A



Presidential Lecture

Monday, July 6 17:00-17:30 Room A

Chemokines: From Discovery to Clinical Development
Speaker: Kouji Matsushima(Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan)


Keynote Lecture 1

Monday, July 6 17:30-18:30 Room A

From IL-6 to TH17; Why Is Anti-IL6R (Tocilizumab) Effective on Antoimmune Diseases?
Chair: Nobuyuki Miyasaka (Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Japan)
Speaker: Tadamitsu Kishimoto (Graduate School of Frontier Biosciences, Osaka University, Japan)

Keynote Lecture 2

Monday, July 6 18:30-19:30 Room A

Induction of Pluripotency by Defined Factors
Chair: Makoto Asashima (Graduate School of Arts and Sciences, The University of Tokyo, Japan)
Speaker: Shinya Yamanaka (Center for iPS Cell Research and Application, Institute for Integrated Cell-Material Sciences/ Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan)

Keynote Lecture 3

Tuesday, July 7 9:00-9:50 Room A

Nucleic Acids-Sensing, Signaling and IRF Transcription Factors in Inflammation and Immunity
Chair: Masayuki Miyasaka (Graduate School of Medicine, Osaka University, Japan)
Speaker: Tadatsugu Taniguchi (Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan)

Keynote Lecture 4

Wednesday, July 8 9:00-9:50 Room A

Initiation and Control of T Cell-Mediated Inflammation
Chair: Kazuhiko Yamamoto (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan)
Speaker: Abul K. Abbas (Department of Pathology, University of California, USA)

Keynote Lecture 5

Thursday, July 9 9:00-9:50 Room A

Treating Inflammation by Inhibition of Chemokine Receptors: Practical Requirements and Efficacy of CCR9 Antagonism in Inflammatory Bowel Disease
Chair: L. Marshall (Inflammatory Diseases, Johnson and Johnson Pharmaceuticals, USA)
Speaker: Thomas J. Schall (ChemoCentryx Inc., USA)

Keynote Lecture 6

Friday, July 10 9:00-9:50 Room A

Tissue Engineering: The Past, the Present, and the Future
Chair: Yasuhiko Tabata (Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Japan)
Speaker: Robert M. Nerem (Parker H. Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology, USA)


Special Lecture1

Tuesday, July 7 13:30-14:15 Room A

Natural Human CD4+CD25high Tregs and Th17 Effector Cells
Chair: Kazuhiko Yamamoto (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan)
Speaker: David Hafler (Department of Neurology, Harvard Medical School, USA)

Special Lecture2

Wednesday, July 8 13:30-14:15 Room A

The Role of Autophagy in Protein Metabolism
Chair: Ikuo Morita (Tokyo Medical and Dental University, Japan)
Speaker: Noboru Mizushima (Department of Physiology and Cell Biology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, Japan)


Morning Symposium 1

Tuesday, July 7 10:00-12:00 Room A

Molecular Basis of Inflammation and Innate Immunity
Chair: Yoichiro Iwakura (Institute of Medical Science, University of Tokyo, Japan) and Joost J. Oppenheim (Laboratory of Molecular Immunoregulation, Cancer & Inflamm. Prog. Center for Cancer Res., National Cancer Inst., NIH, USA)
  1. Negative Regulation of TLR Response
    Speaker: Shizuo Akira (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan)
  2. Activation of Innate Immune Reaction by Mammalian DNA that Escaped from Degradation, Leading to Anemia and Arthritis
    Speaker: Shigekazu Nagata (Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Japan)
  3. The Roles of IL-17A and IL-17F in Inflammation and Host Defense against Bacteria
    Speaker: Yoichiro Iwakura (Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japan)
  4. Alarmins Activate Immune Responses by Inducing Dendritic Cell Chemotaxis and Maturation
    Speaker: Joost J. Oppenheim (Laboratory of Molecular Immunoregulation, Cancer & Inflamm. Prog. Center for Cancer Res., National Cancer Inst., NIH, USA)

Morning Symposium 2

Wednesday, July 8 10:00-12:00 Room A

Inflammation-Associated Tissue Injury and Repair
Chair: Steven L. Kunkel (Department of Pathology, The Immunology Program University of Michigan Medical School,USA) and Robert M. Strieter (Department of Medicine, University of Virginia School of Medicine, USA)
  1. Production of Lipid Mediators during Lands' Cycle
    Speaker: Takao Shimizu (Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan)
  2. Writers, Readers, and Erasers: Dynamic Epigenetic Regulation of Macrophage-Derived Pro-Fibrotic Mediators.
    Speaker: Steven L. Kunkel (Department of Pathology, University of Michigan Medical School, USA)
  3. Fibrocytes as Circulating Mesenchymal Progenitor Cells in Pulmonary Fibrosis: The Importance of the CXCR4/CXCL12 Biological Axis
    Speaker: Robert M. Strieter (Department of Medicine, University of Virginia School of Medicine, USA)
  4. The Lysophosphatidic Acid Receptor LPA1 Mediates Fibrosis in the Lung and Skin Following Injury.
    Speaker: Andrew Luster (Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, USA)

Morning Symposium 3-1(JSIR Sponsored Symposium)

Thursday, July 9 10:00-12:00 Room A

New Strategy for the Discovery of Anti-Inflammatory Drugs
Chair: Shinichi Kawai (Division of Rheumatology, Department of Internal Medicine, Japan) and J. D. Winkler (Discovery and Translational Biology, Array BioPharma Inc. , USA)
  1. Therapeutic Approach to Th1-Type Bronchial Asthma in Transiently Humanized Mice by Using Human Anti-Human IL-18 Antibody.
    Speaker: Kenji Nakanishi (Department of Immunology and Medical Zoology, Hyogo College of Medicine, Japan)
  2. Allosteric Regulation in the Design of Kinase Inhibitors for the Treatment of Inflammatory Disease
    Speaker: Kevin Koch (Array BioPharma Inc. USA)
  3. De Novo Drug Design for PPI (Protein-Protein Interaction) Targets
    Speaker: Takao Matsuzaki (Independent Drug Design Advisor, Japan)
  4. Anti-Inflammatory Lessons Taught by Viruses
    Speaker: Daved Fremont (Department of Pathology and Immunology, Washington University School of Medicine, USA)

Morning Symposium 3-2(JSIR Sponsored Symposium)

Thursday, July 9 10:00-12:00 Room B

Regenerative Medicine - 1
Chair: Tatsutoshi Nakahata (Center for iPS Cell Research and Application(CiRA), Institute for Integrated Cell-Material Sciences, Kyoto University, Japan) and Hideyuki Okano (Department of Physiology, Keio University School of Medicine, Japan)
  1. Future of Regenerative Medicine with Various Stem Cells
    Speaker: Tatsutoshi Nakahata (Center for iPS Cell Research and Application(CiRA), Institute for Integrated Cell-Material Sciences, Kyoto University, Japan)
  2. Neural Differentiation and Cell Therapy Using Pluripotent Stem Cells.
    Speaker: Hideyuki Okano (Graduate School of Medicine, Keio University, Japan)
  3. Regeneration Therapy for Heart Failure
    Speaker: Issei Komuro@(Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Japan)
  4. Induction of Pluripotency in Somatic and Germline Cells
    Speaker: Hans Robert Schoeler (Max Planck Institute for Molecular Biomedicine, Department Cell and Developmental Biology, Germany)

Morning Symposium 4-1(JSIR Sponsored Symposium)

Friday, July 10 10:00-12:00 Room A

Novel Therapeutic Approaches
Chair: Nobuyuki Miyasaka (Department of Medicine and Rheumatology, Tokyo Medical Dental University, Japan) and Ian Ahnfelt-Ronne (BRU Pharmacology, Novo Nordisk A/S, Denmark)
  1. Anti-Osteoclast Therapy for Bone Destruction in Inflammation
    Speaker: Hiroshi Takayanagi (Department of Cell Signaling, Tokyo Medical and Dental University, Japan)
  2. The Role of Endogenous TLR Ligands in Rheumatoid Arthritis.
    Speaker: Richard Pope (Department of Medicine, Northwestern University Feinberg School of Medicine, USA)
  3. Sphingosine 1-Phosphate as a Novel Target for the Therapy of Autoimmune Diseases
    Speaker: Kenji Chiba (Pharmacology, Research Division, Mitsubishi Tanabe Pharma Corporation, Japan)
  4. Beyond Immunosuppressive Treatments of Rheumatoid Arthritis
    Speaker: Hitoshi Kohsaka (Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Japan)

Morning Symposium 4-2(JSIR Sponsored Symposium)

Friday, July 10 10:00-12:00 Room B

Regenerative Medicine - 2
Chair: Minoru Ueda (Nagoya University Graduate Schoo‚Œ of Medicine, Japan) and Teruo Okano (Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Japan)
  1. Cell Sheet Tissue Engineering for Human Clinical Study
    Speaker: Teruo Okano (Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Japan)
  2. Myocardial Regeneration Therapy Using Autologous Cell Sheet
    Speaker: Yoshiki Sawa (Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Japan)
  3. The Future Possibilities of Teeth Pulp Stem Cell for Tissue Engineering Therapy
    Speaker: Minoru Ueda (Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, Japan)
  4. Formation of New Bone and Connective Tissue and the Impact of Implant Material Compositions
    Speaker: Thomas Engstrand (Stockholm Craniofacial Centre, Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm & Department of Materials Chemistry, The Ångström Laboratory, Uppsala University, Sweden)


Workshop 1

Tuesday, July 7 16:45-18:45 Room B

Chair: Akihiko Yoshimura (Keio University, Japan) and Kenji Nakanishi (Department of Immunology and Medical Zoology, Hyogo College of Medicine, Japan)
Category 2. Basic Studies on Inflammation and Immunity.

Workshop 2

Tuesday, July 7 16:45-18:45 Room C

Chair: Takashi Nishimura (Division of Immunoregulation, Institute for Genetical Medicine, Hokkaido University, Japan) and Narinder Mehra (Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, India)
Category 5. Inflammatory Mediators, such as Lipid Mediators, Coagulation, Complements, Cytokines, Chemokines, Free Radicals, and Proteases.
Category 6. Receptors, Signaling Molecules, Nuclear Factors, Protein Kinases/Phosphatases, Enzymes, System Biology
Category 16. Others

Workshop 3

Tuesday, July 7 16:45-18:45 Room D

Chair: Shinji Shimada (University of Yamanashi, Japan) and Ian Adcock (Department of Airways Disease, NHLI, Imperial College London, UK)
Category 1. Disease Models
Category 7. Inflammatory Diseases(1)
Category 16. Others

Workshop 4

Wednesday, July 8 16:45-18:45 Room A

Chair: Tatsuro Irimura (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan) and John Romer (Director of Histology, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Denmark)
Category 7. Inflammatory Diseases(2)
Category 8. Inflammatory Diseases Caused by Infection

Workshop 5

Wednesday, July 8 16:45-18:45 Room B

Chair: Osamu Yoshie (Department of Microbiology, Kinki University School of Medicine, Japan) and Teizo Yoshimura (Laboratory of Immunoregulation Cancer and Inflammation Program Center for Cancer Research National Cancer Institute at Frederick, USA)
Category 3. Lymphocytes, Macrophages, Neutrophils, Other Inflammatory Cells
Category 9. Cancer and Inflammation, Angiogenesis
Category 12. Clinical Tests: Biomarkers, Bio-Imaging, Epigenetics, SNP, Gene Expression
Category 16. Others

Workshop 6

Wednesday, July 8 16:45-18:45 Room C

Chair: Masataka Majima (Department of Pharmacology, Kitasato University School of Medicine, Japan) and Graham Wallace (School of Immunity and Infection, University of Birmingham, UK)
Category 10. Drug Discovery: Moleculear Targets, Drug Screening, Drug Design, Informatics, Molecular Library, Genetics and Genomics, Devices
Category 11. Natural Products
Category 13. Action Mechanisms of Anti-Inflammatory Drugs
Category 14. Development of Novel Therapeutics
Category 16. Others

Workshop 7

Wednesday, July 8 16:45-18:45 Room D

Chair: Yasuhiko Tabata (Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Japan) and Fernando Q Cunha (Department of Pharmacology, School of Medicine Ribeirao Preto, University of Sao Paulo, Brazil)
Category 15. Regenerative Medicine: Cell Therapy, Mesenchymal Stem Cells, ES, Neural and Other Organ Specific Stem/Progenitor Cells, Materials, etc.


Young Investigator's Award Contestants' Session (Van Arman Award)

Thursday, July 9 14:15-16:15 Room A

Chair: Gordon Letts (Targanox Inc., USA) and Richard P. Carlson (Research Consultant, USA)

Introduction
Life and Scientific Career of C.Gordon Van Arman, Ph.D.
Speaker: Richard P. Carlson

  1. Crucial Involvement of the CCR2/CCL2 Interactions in Azoxymethane/Dextran Sodium Sulfate-induced
    Colon Carcinognesis in Mice
    Speaker: Boryana K Popivanova
    (Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Japan)
  2. Adipose Tissue Remodeling, Chronic Inflammation and T-cell-macrophage Interactions in Obesity Visualized by in vivo Molecular Imaging Methods
    Speaker: Satoshi Nishimura
    (Department of Cardiovascular Medicine, The University of Tokyo, Nano-bioengineering Education Program, The University of Tokyo, PRESTO, Japan Science and Technology Agency, Japan)
  3. The Roles of Endogenously-produced Chemokines in the Development of Tissue-specific Myeloid-lineage Cells and Macrophages
    Speaker: Akiyoshi Hoshino
    (International Clinical Research Center, Research Institute, International Medical Center of Japan, Japan)
  4. Prostaglandin E Receptor Subtypes EP2 and EP4 Promote TH1 Cell Differentiation and TH17 Cell Expansion Through Different Signaling Modules
    Speaker: Daiji Sakata
    (Department of Pharmacology, Faculty of Medicine, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan)
  5. Increased Human Vascular Reactivity via Cyclooxygenase-2 Inhibition during Acute Inflammation: Role of Prostaglandins E2 AND I2
    Speaker: Nabil Foudi
    (INSERM U698: Haemostasis, Bio-engineering and Cardiovascular Remodeling, Paris XIII University,
    Villetaneuse, France)
  6. Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse
    Speaker: Neil Peter Dufton
    (William Harvey Research Institute, Queen Mary University of London, UK)
  7. Selective ƒÀ-adrenergic Receptor Expression on Human Memory CD8+ T Lymphocyte Subsets Regulates Mobilization and INF-y Production
    Speaker: Natalie E. Riddell
    (School of Sport & Exercise Sciences, University of Birmingham, UK)
Women in Inflammation Science Award Lecture

Thursday, July 9 16:15-17:00 Room A

Inflammation, Sensory Nerves and the Cough Reflex
Chair: Lisa Marshall (Inflammatory Diseases, Johnson and Johnson Pharmaceuticals, USA)
Nominee: Maria G. Belvisi(Department of National Heart and Lung Institute,Imperial College London,UK)

Inflammation Lifetime Achievement Award Lecture

Thursday, July 9 17:10-18:00 Room A

Prostanoids in inflammation; a new concept arising from receptor-knockout mouse studies
Chair: Alan Lewis (JDRF International, USA) and Kouji Matsushima (Graduate School of Medicine and Faculty of Medicine, the University of Tokyo, Japan)
Nominee: Shuh Narumiya (Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan)



Society Sponsored Symposium 1
Sponsored by IRA - Inflammation Research Association (USA)

Tuesday, July 7 14:30-16:30 Room B

Translational Medicine Approaches to Improve the Probability of Success for Inflammation Drug Development
Chair: Lisa Marshall (Inflammatory Diseases, Johnson and Johnson Pharmaceuticals, USA)
and James Winkler (Discovery and Translational Biology, Array BioPharma Inc., USA)
  1. Successes and Failures of Biomarker Use in Phase I/2a Clinical Trials Targeting Inflammatory Diseases
    Speaker: Lisa Marshall (Inflammatory Diseases, Johnson and Johnson Pharmaceuticals, USA)
  2. Automated Chemotaxis Drug Screening System Based on TAXIScan Technology
    Speaker: Shiro Kanegasaki (Central Lab, ECI, Inc., Japan)
  3. Synovial Biopsies: Use as a Predictive Marker of Treatment Efficacy in Early Development
    Speaker: Danielle Gerlag (Division of Clinical Immunology and Rheumatology, University of Amsterdam, the Netherlands)
  4. Dissecting the Roles of p38 and MEK: Links between Preclinical and Clinical Results
    Speaker: James Winkler (Discovery and Translational Biology, Array BioPharma Inc., USA)

Society Sponsored Symposium 2
Sponsored by CAN - Canadian Arthritis Network

Tuesday, July 7 14:30-16:30 Room C

Bioactive Lipids and the Inflammatory Response; Cellular and Molecular Mechanisms
Chair: John A. Di Battista (Department of Medicine, McGill University and the Division of Rheumatology, McGill University Health Centre, Montreal, Quebec, Canada)
  1. Impact of Prostaglandin E2 and Cyclic AMP-Elevating Agents on the Gene Expression Profile of Stimulated Human Neutrophils: Unraveling Endogenous Resolution Pathways.
    Speaker: Marc Pouliot (Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ-CHUL et Université Laval, Québec, Canada)
  2. Autotaxin and Lysophospholipids in Rheumatoid Arthritis.
    Speaker: Sylvain G. Bourgoin (Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ-CHUL et Université Laval, Québec, Canada)
  3. Phospholipases A2 in the Life and Death of Human Osteoclasts.
    Speaker: Artur J. de Brum-Fernandes (Division of Rheumatology, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Québec, Canada)
  4. Modulation of the Inflammatory and Catabolic Response by Prostaglandin E2 (PGE2 )Is Partially Dependent on the Induction of Dual Specificity Phosphatase 1 (DUSP-1) in Vitro and in Vivo.
    Speaker: John A. Di Battista (Department of Medicine, McGill University and the Division of Rheumatology, McGill University Health Centre, Montreal, Quebec, Canada)

Society Sponsored Symposium 3
Sponsored by SCIL - Society for Cytokines, Inflammation and Leukocytes (Australia)

Tuesday, July 7 14:30-16:30 Room D

The Control of Leukocyte Function in Inflammation
Chair: Eric Morand (Centre for Inflammatory Diseases, Monash University, Monash Medical Centre Clayton, Melbourne Australia) and John Hamilton (Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Victoria, Australia)
  1. The Control of Macrophage Phenotypes in Inflammation
    Speaker: John Hamilton (Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Victoria, Australia)
  2. MIF-Promotes Leukocyte Recruitment, via Effects on Function of Both Leukocyte and Endothelial Cells
    Speaker: Michael Hickey (Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Melbourne, Australia)
  3. The Interplay Between Toll-Like Receptor and CSF-1 Signaling Can Set the Level of Macrophage Activation
    Speaker: Glen Scholz (Department of Medicine, University of Melbourne, Australia)
  4. GILZ: a Glucocorticoid - Regulated Modulator of Inflammation - a Role in Rheumatoid Arthritis
    Speaker: Eric Morand (Centre for Inflammatory Diseases, Monash University, Monash Medical Centre Clayton, Melbourne, Australia)

Society Sponsored Symposium 4
Sponsored by BIRAs - British Inflammation Research Association

Wednesday, July 8 14:30-16:30 Room B

Aging, Complex Disease, and Inflammation
Chair: Paul Kirkham (Imperial College London, UK) and Graham Wallace (Birmingham, UK)
  1. The Okinawa Diet: A Nutritional Approach to Modulating gInflammagingh
    Speaker: D. Craig Willcox (Okinawa International University, Okinawa, Japan)
  2. Chronic Inflammation and Disease ? the Link to Oxidative Stress and Ageing
    Speaker: Paul G Winyard (Peninsula Medical School, St Luke's Campus, University of Exeter, UK)
  3. Aerobic Metabolism, inflammation and Susceptibility to Complex Diseases
    Speaker: Christopher S. Stevenson (Respiratory Pharmacology Group, Centre for Integrative Mammalian Physiology and Pharmacology, Imperial College London School of Medicine at the National Heart and Lung Institute London, UK)
  4. Potential Strategies to Overcome Aging - The Link to Chronic Inflammatory Disorders
    Speaker: Iain C. Kilty (Allergy and Respiratory Research Unit, Pfizer Global Research and Development, Sandwich, UK)

Society Sponsored Symposium 5
Sponsored by BIS - Brazilian Inflammation Society

Wednesday, July 8 14:30-16:30 Room C

Mechanisms and Novel Drugs for Systemic Inflammatory Diseases
Chair: B Boris Vargaftig (Department of Pharmacology, Institute of Biomedical Sciences, USP, São Paulo, Brazil) and Mauro Teixeira (Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil)
  1. Ivan Bonta's contribution to the understanding of pulmonary vascular lesions; an extension to ischaemia/reperfusion mechanisms and inhibition by estrogens
    Speaker: B Boris Vargaftig (Department of Pharmacology, Institute of Biomedical Sciences, USP, Sao Paulo, Brazil)
  2. Mechanisms of Disease in Experimental Dengue Infection. Role of Platelet Activating Factor
    Speaker: Mauro M. Teixeira (Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais Brail)
  3. Recognition of Damaged Self and Non-Self Pathogen by C-Type Lectin Receptor, Mincle
    Speaker: Sho Yamasaki (Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Japan)
  4. Failure of Neutrophil Migration to Infection Focus Correlates with Sepsis Outcome: Critical Role of Nitric Oxide- Guanilate Cyclase- cGMP- Protein Kinase G Pathway
    Speaker: Fernando Queiróz Cunha (Departments of Pharmacology, School of Medicine Ribeirão Preto, University of São Paulo, Brazil)

Society Sponsored Symposium 6
Sponsored by Groupe de Recherche et d'Étude des Médiateurs de l'Inflammation (France)

Wednesday, July 8 14:30-16:30 Room D

Inflammasome Activation by Microbes and Danger Signals
Chair: Vincent Lagente (University of Rennes 1, INSERM U620 France) and Laurent Baud (Université Paris 36 INSERM U702, France)
  1. The NALP3 Inflammasome: Guardian of Our Body
    Speaker: Jurg Tschopp (Department of Biochemistry, Center of Immunology Lausanne, University of Lausanne, Epalinges, Switzerland)
  2. Ubiquitin Modification in Innate Immunity
    Speaker: Vishva Dixit (Genentech, Inc. Physiological Chemistry - Research San Francisco CA, USA)
  3. Biological Functions of ASC, a key Mediator Protein for Inflammasome Formation
    Speaker: Shun'ichiro Taniguchi (Shinshu University Graduate School of Medicine, Japan)
  4. Uric acid, NALP3 Inflammasome activation and IL-1R1/MyD88 signaling are essential in bleomycin induced pulmonary inflammation and fibrosis
    Speaker: Isabelle Couillin (CNRS, University of Orleans, Orleans, France)

Society Sponsored Symposium 7
Sponsored by Chinese Inflammation Research Group

Thursday, July 9 14:30-16:30 Room B

Inflammation Research in China
Chair: Jian-Ping Zuo (Lab of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China) and Yanyun Zhang (Shanghai Institute of Immunology and Institute of Health Sciences, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China)
  1. SHP-1 Oppositely Regulates Proinflammatory Cytokine and Type I Interferon Production in TLR-Mediated Innate Immune Responses
    Speaker: Huazhang An (Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China)
  2. The Mechanisms and Therapeutic Effects of (5R)-5-hydroxytriptolide (LLDT-8) in Collagen-Induced Arthritis in DBA/1 Mice
    Speaker: Jian-Ping Zuo (Lab of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China)
  3. Does Inflammation Cut to the gBrain and Hearth of the Matter?
    Speaker: Xiaohui Li (Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, China)
  4. Dynamic Expression of CXCR3 on Alloreactive T Cells Hampers Its Neutralizing Antibody-Mediated GVHD Inhibition
    Speaker: Yanyun Zhang (Shanghai Institute of Immunology and Institute of Health Sciences, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China)
  5. A Trichosanthin-Derived Peptide Tetramer Is Capable of Depressing Inflammation in Autoimmune CIA and EAE by Activation of IL-10/IL-4-Secreting CD8(+)CD28(-)CTLA4(+) Tregs
    Speaker: Guang-Yan Zhou (Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, China)

Japan - Taiwan Joint Symposium on Inflammation Research

Wednesday, July 8 19:00-21:00 Room C

Chair: Wen-Chang Chang (National Cheng Kung University, Taiwan), Ikuo Morita (Tokyo Medical and Dental University, Japan), Chien-Huang Lin (Taipei Medical University, Taiwan), Masataka Majima (Kitasato University, Japan)
  1. Loss of IKKB Activity Increases P53 Stability Leading to Cell Cycle Arrest and Apoptosis
    Speaker: Ching-Chow Chen (Department of Pharmacology, College of Medicine, National Taiwan University, Taiwan)
  2. Role of Prostaglandins in Enhancement of Tumor-Associated Angiogenesis and Tumor Growth
    Speaker: Masataka Majima (Department of Pharmacology, Kitasato University School of Medicine, Japan)
  3. FAS Mediated Caspase-Independent Cell Death and Inflammatory Responses
    Speaker: Wan-Wan Lin (Department of Pharmacology, National Taiwan University, Taiwan)
  4. Adipose Tissue Remodeling, Chronic Inflammation and T-Cell-Macrophage Interactions in Obesity Visualized by in Vivo Molecular Imaging Methods
    Speaker: Satoshi Nishimura (Department of Cardiovascular Medicine, The University of Tokyo, Nano-bioengineering Education Program, The University of Tokyo, PRESTO, Japan Science and Technology Agency, Japan)
  5. Regulation of Chemokine Gene Expression by Hypoxia Via Cooperative Activation of NF-κB and HDAC
    Speaker: Olga Sergeevna Safronova (Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, Japan)
  6. Glycogen Synthase Kinase-3ƒÀ Facilitates IFN-ƒÁ-Induced-Induced STAT1 Activation by Regulating SRC Homology-2 Domain-Containing Phosphatase 2
    Speaker: Chiou-Feng Lin (Institute of Clinical Medicine, National Cheng Kung University, Taiwan)
  7. Epidermal Growth Factor-Activated ARNT/HIF-1 ƒÀ Signal Pathway Up-Regulates Cyclooxygenase-2 Gene Expression Associated With Squamous Cell Carcinoma
    Speaker: Ben-Kuen Chen (Institute of Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Taiwan)
  8. Prostaglandin E2-EP4 Signaling Promotes Immune Inflammation Through TH1 Cell Differentiation and TH17 Cell Expansion
    Speaker: Daiji Sakata (Department of Pharmacology, Faculty of Medicine, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan)
Industry Sponsored Symposium 1
Sponsored by GlaxoSmithKline K. K.

Tuesday, July 7 14:30-16:30 Room A

Role of Inflammation in the Etiology of Obstructive Lung Diseases And the Treatment Strategy
Chair: Shoji Kudoh (Double-Barred Cross Hospital, Japan Anti-Tuberuclosis Association, Japan) and Hajime Takizawa (Fourth Department of Internal Medicine, Teikyo University, School of Medicine, Japan)
  1. Pathogenesis and Treatment of Diffuse Panbronchiolitis
    Speaker: Jun Tamaoki (First Department of Medicine, Tokyo Women's Medical University, Japan)
  2. Role of Inflammation in the Pathogenesis of Asthma
    Speaker: Mitsuru Munakata (Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Japan)
  3. Aging Enhances Susceptibility to Cigarette Smoke-Induced Inflammation
    Speaker: Tomoko Betsuyaku (First Department of Medicine, Hokkaido University School of Medicine, Japan)
  4. Targeting Chemokine Receptors: A Novel Oral CXCR2 Antagonist SB-656933 from Discovery to Clinical Development
    Speaker: Ruth Tal-Singer (Respiratory Centre for Excellence for Drug Discovery GlaxoSmithKline King of Prussia, PA USA)

Industry Sponsored Symposium 2
Sponsored by Chugai Pharmaceutical Co., Ltd

Tuesday, July 7 16:45-18:45 Room A

IL-6 in Autoimmunity and Inflammation
Chair: Kazuyuki Yoshizaki (Center for Advanced Science and Innovation, Osaka University, Japan) and Chen Dong (Department of Immunology, University of Texas M.D. Anderson Cancer Center, USA)
  1. IL-6 in Regulation of Novel Subsets of T Cells
    Speaker: Chen Dong (Department of Immunology, University of Texas M.D. Anderson Cancer Center, USA)
  2. Is Dysregulation of IL-6 Amplifier a Key Event of Rheumatoid Arthritis?
    Speaker: Toshio Hirano (Laboratory of Developmental Immunology and the CREST Program of the Japan Science and Technology Agency, Graduate School of Frontier Biosciences, Graduate School of Medicine, and WPI Immunology Frontier Research Center, Osaka University, Osaka and Laboratory of Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan)
  3. A Crucial Role of IL-6/IL-17 Cytokine Axis in the Generation of Glucose-6-Phosphate Isomerase-Induced Arthritis
    Speaker: Isao Matsumoto (Division of Clinical Immunology, Doctoral Program in Clinical Science, Graduate of Comprehensive Human Sciences, University of Tsukuba, Japan)
  4. Role of IL-6 Blocking Therapy for Improvement of Autoimmune Disease in Chronic Inflammatory Status
    Speaker: Kazuyuki Yoshizaki (Center for Advanced Science and Innovation, Osaka University, Japan)

Industry Sponsored Symposium 3
Sponsored by Abbott Japan Co., Ltd. / Eisai Co., Ltd

Wednesday, July 8 14:30-16:30 Room A

The Irreversibility of the Bone Erosion and Radiographic Damages in RA
Chair: Nobuyuki Miyasaka (Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Japan) and Ferdinand C Breedveld (Head of the Department of Rheumatology and Chairman of the Department of Medicine, Leiden University Medical Center, the Netherlands)
  1. Clinical Management in RA Is Not Enough, Bone Erosion Is Irreversible Leading to the Burden of the Disease (Functionality, Work Productivity)
    Speaker: Paul Peter Tak (Division of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, the Netherlands)
  2. Treatment Algorithm: What Can We Expect from DMARDs and BDMARDs - Clinical Versus Radiographic Effects
    Speaker: Ferdinand C Breedveld (Head of the Department of Rheumatology and Chairman of the Department of Medicine Leiden University Medical Center, the Netherlands)
  3. TNF-α and Bone Destruction in Arthritis -from the Viewpoint of Basic Research-
    Speaker: Hiroshi Takayanagi (Department of Cell Signaling, Tokyo Medical and Dental University, Japan)
  4. HUMIRA : for a Long Term and Comprehensive RA Disease Management - Clinical Data, Radiographic Data, Functionally Data, Work Productivity Data-
    Speaker: Tsutomu Takeuchi (Division of Rheumatology, Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan)

Industry Sponsored Symposium 4
Sponsored by Mitsubishi Tanabe Pharma Corporation

Thursday, July 9 12:10-14:10 Room C

The Inflammatory Bowel Disease and Gut Mucosal Immunology
Chair: Toshifumi Hibi (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan) and Masayuki Miyasaka (Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Japan)
  1. The Central Role of IL-25 in Regulating Immunity and Inflammation in the Intestine
    Speaker: Colby Zaph (The Biomedical Research Centre, University of British Columbia, Canada)
  2. Regulatory Antigen Presenting Cells in the Gut.
    Speaker: Myoung Ho Jang (Laboratory of Gastrointestinal Immunology, WPI Immunology Frontier Research Center, Osaka University, Japan)
  3. Mechanism of Th17 Cell Differentiation in the Intestinal Lamina Propria
    Speaker: Kenya Honda (Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, Japan)
  4. Intestinal Macrophages and NK Cells Play a Crucial Role for the Pathogenesis of Crohn's Disease
    Speaker: Tadakazu Hisamatsu, Toshifumi Hibi (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan)


Luncheon Seminar 1
Sponsored by Novo Nordisk

Tuesday, July 7 12:10-13:10 Room B

Disease Association of IL-20 with Arthritis
Chair: Ian Ahnfelt-Ronne (BRU Pharmacology, Novo Nordisk A/S, Denmark)
  1. Evidence that Cytokines Play a Role in Rheumatoid Arthritis.
    Speaker: Iain B McInnes (Glasgow Biomedical Research Centre, University of Glasgow, Scotland)
  2. A Role of IL-20 in Rheumatoid Arthritis
    Speaker: Paul Peter Tak (Division of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, the Netherlands)

Luncheon Seminar 2
Sponsored by Wyeth K.K. / Takeda Pharmaceutical Company Limited

Tuesday, July 7 12:10-13:10 Room C

TNF Inhibition: A Quantum Leap in Therapy of Rheumatic Diseases
Chair: Takao Koike (Department of Medicine , Clinical Immunology and Metabolism, Internal Medicine, Graduate School of Medicine, Hokkaido University , Japan)
Speaker: Wayne Tsuji (Amgen, Inc., USA)

Luncheon Seminar 3
Sponsored by Astellas Pharma Inc. / Pfizer Japan Inc.

Tuesday, July 7 12:10-13:10 Room D

An Update on COX-2 Inhibitor's Cardiovascular Risk
Chair: Nobuyuki Miyasaka (Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Japan)
Speaker: Gary W. Williams, M.D., Ph.D. (Chairman, Department of Medicine, Vice President, Medicine Services and Medical Director of Information Services, Scripps Clinic, La Jolla, California, Skaggs Scholar, The Scripps Research Institute, La Jolla, California, USA)

Luncheon Seminar 4
Sponsored by Kyowa Hakko Kirin Co., Ltd.

Wednesday, July 8 12:10-13:10 Room B

Antimicrobial Peptides: Local Host Response Elements of the Epithelial Defense System
Chair: Naofumi Mukaida (Division of Molecular Bioregulation Cancer Research Institute, Kanazawa University, Japan)
Speaker: Jens-M. Schroeder (Professor for the Biochemistry of Inflammation, Head Clinical Research Unit "Cutaneous Inflammation" Department of Dermatology, University Hospital Schleswig-Holstein, Germany)

Luncheon Seminar 5
Sponsored by Zenyaku Kogyo Co., Ltd.

Wednesday, July 8 12:10-13:10 Room C

Human B Cell Diversity and Immunological Tolerance
Chair: Yoshiya Tanaka (Professor & Chairman, The First Department of Internal Medicine
School of Medicine and Deputy Director, University of Occupational & Environmental Health, Japan)
Speaker: Iñaki Sanz (Clinical Immunology & Rheumatology Unit, University of Rochester Medical Center, USA)

Luncheon Seminar 6
Sponsored by TEIJIN Pharma Limited

Wednesday, July 8 12:10-13:10 Room D

Recent Progress in Innate Immunity: Autophagy and Inflammation
Chair: Hiroshi Takayanagi (Department of Cell Signaling, Tokyo Medical and Dental University, Japan)
Speaker: Shizuo Akira (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan)

Luncheon Seminar 7
Sponsored by Otsuka Pharmaceutical Co., Ltd.

Thursday, July 9 12:10-13:10 Room B

Chemokines and Inflammation in Kidney
Chair: Tsuneyo Mimori (Department of Rheumatology and Clinical Immunology Graduate School of Medicine , Kyoto University, Japan)
Speaker: Takashi Wada (Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Japan)


Evening Seminar
Sponsored by Argenes, Inc.

Wednesday, July 8 19:00-21:00 Room B

Novel Paradigm of Inflammation@\Apoptosis and Autoinflammatory\
Chair: Kusuki Nishioka (Institute of Medical Science, St. Marianna University School of Medicine) and Shumpei Yokota (Department of Pediatrics, Yokohama City University, Yokohama, Japan)
  1. Programmed Cell Death and Autoimmune Diseases
    Speaker: Shigekazu Nagata (Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
  2. A Novel Anti-Human Fas Antibody Shows Strong Cytotoxic Effect on Rheumatoid Arthritis Synoviocytes and Infiltrating Lymphocytes.
    Speaker: Kusuki Nishioka (Institute of Medical Science, St. Marianna University School of Medicine)
  3. Autoinflammatory Diseases in Childhood: Clinical and Genetic Advances
    Speaker: Shumpei Yokota (Department of Pediatrics, Yokohama City University, Yokohama, Japan)
  4. Autoinflammatory syndrome from the aspect of Internal Medicine
    Speaker: Hiroaki Ida (First Department of Internal Medicine, Nagasaki University Hospital of Medicine and Dentistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan)


Public Seminar

Friday, July 10 13:15-15:15 Room A

*Presented in Japanese



























IAIS