Program::The 90th Annual Meeting of The Japanese Pharmacological Society -Therapeutic innovation of Dejima-

Plenary Lecture

Speaker: Kazutoshi Mori (Department of Biophysics, Division of Biological Sciences, Graduate School of Science, Kyoto University, Japan)

Dynamics of Function and Regulation of the Endoplasmic Reticulum (ER)

Chair	Hiroshi Ueda (Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences, Japan)

March 16 (Thu) 14:00-15:00 Room A (Nagasaki Brick Hall Main Hall)

Special Lecture

Speaker: Nagahiro Minato (Graduate School of Medicine, Kyoto university, Japan)

Checkpoint blockade cancer immunotherapy: history and future perspectives

Chair	Shuh Narumiya (The Medical Innovation Center Kyoto University, Graduate School of Medicine, Japan)

March 15 (Wed) 9:00-10:00 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Eunjoon Kim (IBS and KAIST, Korea)

NMDA receptor dysfunction in autism spectrum disorders

Chair	Jun Aruga (Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Japan)

March 15 (Wed) 14:10-15:10 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Masamitsu Iino (Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Japan)

Calcium signaling: From in vivo imaging to pathophysiological analyses

Chair	Nobuyuki Yanagihara (Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Japan)

March 15 (Wed) 15:20-16:20 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Takao Shimizu (National Center for Global Health and Medicine, Japan)

Mechanism and biological output of membrane phospholipid diversity

Chair	Masayoshi Mishina (The Research Organization of Science and Technology, Ritsumeikan University, Japan)

March 16 (Thu) 9:00-10:00 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Hiroshi Takayanagi (Department of Immunology Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan)

Osteoimmunology and the progress of treatment of bone and joint diseases

Chair	Atsushi Kawakami (Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan)

March 16 (Thu) 10:10-11:10 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Masashi Yanagisawa (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan)

Towards the Mysteries of Sleep

Chair	Norio Matsuki (Policy Alternatives Research Institute, Japan)

March 16 (Thu) 15:25-16:25 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Masayuki Yamamoto (Tohoku University Graduate School of Medicine, Tohoku Medical Megabank Organizaton, Japan)

Molecular basis of environmental stress response and diseases

Chair	Kazuhiko Yanai (Department of Pharmacology, Tohoku University, School of Medicine, Japan)

March 17 (Fri) 9:00-10:00 Room A (Nagasaki Brick Hall Main Hall)

Speaker: Takaomi Saido (RIKEN Brain Science Institute, Japan)

The next-generation mouse models of Alzheimer's disease

Chair	Nobuhisa Iwata (Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Japan)

March 17 (Fri) 13:00-14:00 Room A (Nagasaki Brick Hall Main Hall)

Special Guest Lecture

* Collaboration program with the Annual Meeting Special Symposium

Speaker: Daniel Goldman (Molecular & Behavioral Neurosciences Institute and Department of Biochemistry, University of Michigan, USA)

Müller glia and retina regeneration

Chair	Hiroshi Ueda (Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences, Japan)

March 15 (Wed) 13:00-13:40 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

Speaker: Masayo Takahashi (Laboratory for Retinal Regeneration RIKEN Center for Developmental Biology, Japan)

Retinal cell therapy using iPS cells

Chair	Hideaki Hara (Molecular Pharmacology, Gifu Pharmaceutical University, Japan)

March 15 (Wed) 13:40-14:20 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

JPS-ASCEPT Lecture

Speaker: Mary Chebib (University of Sydney, Australia)

Targeting binary GABA_A receptors : A possible role for zolpidern in stroke and motor recovery

Chair	Atsuro Miyata (Kagoshima University Graduate School of Medical & Dental Sciences Department of Pharmacology, Japan)

March 15 (Wed) 10:30-11:30 Room A (Nagasaki Brick Hall Main Hall)

Ebashi Setsuro Award Lecture

Speaker: Yuji Ikegaya (Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Studies on Function and Pathology of Brain Circuits

Chair	Hiroshi Iwao (Shitennoji University, Japan)

March 16 (Thu) 13:00-14:00 Room A (Nagasaki Brick Hall Main Hall)

Encouragement of Young Investigator Award Lecture

Speaker	Kazunori Kanemaru (Department of Cellular and Molecular Pharmacology, Graduate School of Medicine, The University of Tokyo) Analysis of astrocytic function using Ca²⁺ imaging
	Takuya Sasaki (Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo) Functional dynamics of brain cell networks in health and disease
	Norifumi Shioda (Department of Bio Functional Analysis Laboratory of Molecular Biology Gifu Pharmaceutical University) Elucidation of intracellular signaling mechanism mediated by dopamine D₂ receptor
Chair	Hisashi Hashimoto (Laboratory of Molecular Neuropharmacology, Osaka University)

March 16 (Thu) 16:40-17:40 Room A (Nagasaki Brick Hall Main Hall)

Educational Seminar

Speaker: Hideo Kimura (Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Japan

Signaling molecules: hydrogen sulfide (H₂S) and polysulfides (H₂S_n)

Chair	Yuji Ikegaya (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)

March 15 (Wed) 15:20-15:55 Room B (Nagasaki Brick Hall International Conference Hall)

Speaker: Yoshio Goshima (Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Japan)

L-DOPA neurotransmitter hypothesis

Chair	Yuji Ikegaya (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)

March 15 (Wed) 15:55-16:30 Room B (Nagasaki Brick Hall International Conference Hall)

JPS Satellite Symposium

Efficient Drug Development by using State-of-the-art Imaging Technologies

Chair	Yasuyoshi Watanabe (RIKEN CLST)
Speaker	Atsushi Miyawaki (RIKEN BSI), Christer Halldin (Karolinska Institutet, Sweden), Tetsuya Suhara (NIRS, QST), Bernd J. Pichler (Eberhard Karls Univ. of Tübingen, Germany), Yasuyoshi Watanabe (RIKEN CLST)

March 17 (Fri) 9:00-11:30 Room B (Nagasaki Brick Hall International Conference Hall)

Annual Meeting Symposium

New perspective of pharmacology education: to question the propriety of pharmacology educator license

Chair	Yuji Ikegaya (Univ. of Tokyo), Atsuro Miyata (Kagoshima Univ.)
Speaker	Noriyuki Koibuchi (Officers & Education Committees, The Physiological Society of Japan), Teruyuki Yanagisawa (Tohoku Univ.)

March 15 (Wed) 13:00-14:30 Room J (Nagasaki Brick Hall Practice Room1)

Academic Drug Discovery

Chair	Masatoshi Hagiwara (Kyoto Univ.), Hiroshi Ueda (Nagasaki Univ.)
Speaker	Toshiyuki Nihei (MEXT), Shuichi Tawara (AMED), Yuichi Deguchi (Nagasaki Univ.), Masatoshi Hagiwara (Kyoto Univ.), Soichi Kojima (RIKEN CLST)

March 15 (Wed) 13:00-15:00 Room B (Nagasaki Brick Hall International Conference Hall)

Pharmacological research benefits returnable for inauguration

Chair	Yukio Yoneda (Kanazawa Univ.)
Speaker	Masami Niwa (PharmaCo-Cell Co., Ltd.), Yuji Imaizumi (Nagoya City Univ.), Yukio Yoneda (Kanazawa Univ.)
Debater	Shizuo Yamada (Univ. Shizuoka)

March 15 (Wed) 13:00-14:30 Room D (Nagasaki Brick Hall Meeting Room 1, 2, 3)

New Challenge of Cancer Therapy - Cutting edge of multidisciplinary teams harmonized with basic and clinic -

Chair	Yasuo Takeda (Kagoshima Univ.)
Speaker	Motoya Mie (Kyowa Hakko Kirin Co., Ltd.), Minoru Fukuda (Nagasaki Univ.), Hiroyuki Watanabe (Kyushu Univ. Hospital)

March 15 (Wed) 13:00-14:30 Room I (Nagasaki AstopIa SANGO Hall)

Frontiers in drug development targeting DAMPs with dual Yin and Yang nature

Chair	Masahiro Nishibori (Okayama Univ.)
Speaker	Masahiro Nishibori (Okayama Univ.), Takashi Shichita (Keio Univ.), Hiroshi Ueda (Nagasaki Univ.)

March 17 (Fri) 10:05-11:35 Room D (Nagasaki Brick Hall Meeting Room 1, 2, 3)

Healthy Longevity to learn from Oral Brain Science

Chair	Hiroshi Nakanishi (Kyushu Univ.), Kazuhiro Takuma (Osaka Univ.)
Speaker	Masayuki Kobayashi (Nihon Univ.), Makoto Inoue (Niigata Univ.), Zhou Wu (Kyushu Univ.)

March 17 (Fri) 10:05-11:35 Room H (Nagasaki AstopIa SHINJYU Hall)

Leading-edge studies for diabetic nephropathy

Chair	Akira Nishiyama (Kagawa Univ.)
Speaker	Akira Nishiyama (Kagawa Univ.), Kei Fukami (Kurume Univ.), Takeshi Marumo (Univ. of Tokyo)

March 17 (Fri) 12:50-14:20 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

Annual Meeting Special Symposium

* Collaboration program with the Special Guest Lecture

Current and future for the therapies of retinal diseases - Basic and clinical studies of retinal regeneration, iPS and retinal neovascularization -

Chair	Hideaki Hara (Gifu Pharm. Univ.), Takashi Kitaoka (Nagasaki Univ.)
Speaker	Hideaki Hara (Gifu Pharm. Univ.), Makiko Matsumoto (Nagasaki Univ.)

March 15 (Wed) 13:00-15:30 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

Annual Meeting Company-Sponsored Symposium

Pharmacological research of traditional Japanese medicine (Kampo medicine) in top journals in science - Possible role of rikkunshito as an endogenous ghrelin enhancer -

Chair	Yasuhito Uezono (Natl. Cancer Ctr. Res. Inst.)
Speaker	Hiroshi Takeda (Hokkaido Univ.), Yasuhito Uezono (Natl. Cancer Ctr. Res. Inst.), Akio Inui (Kagoshima Univ.)

March 17 (Fri) 10:05-11:35 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

Annual Meeting Nano Symposium

Pharmacology of functional foods

Chair	Shizuo Yamada (Univ. of Shizuoka)
Keynote Lecture	Akira Iino (Food Labeling Planning Division, Consumer Affairs Agency)
Speaker	Yasuo Watanabe (Yokohama Univ. of Phaemacy), Yasuhiko Izumi (Kyoto Univ.), Nobuyuki Kuramoto (Setsunan Univ.), Yoshihiko Ito (Univ. of Shizuoka), Yasumasa Ikeda (Tokushima Univ.)

March 17 (Fri) 12:50-14:50 Room H (Nagasaki AstopIa SHINJYU Hall)

Joint Symposium with the Japanese Medical Science Federation

Drug discovery for mitochondrial diseases - Turning point in a new era

Chair	Takaaki Abe (Tohoku Univ.), Naohiko Anzai (Chiba Univ.)
Speaker	Seiji Takashima (Osaka Univ.), Toshihiko Oka (Rikkyo Univ.), Abe Takaaki (Tohoku Univ.), Tsumoto Kohei (Univ. of Tokyo)

March 16 (Thu) 10:10-11:40 Room H (Nagasaki AstopIa SHINJYU Hall)

Joint Symposium with the Physiological Society of Japan

Advanced molecular biological research in pain, itch and dysesthesia

Chair	Makoto Tominaga (Okazaki Inst.), Atsufumi Kawabata (Kindai Univ.)
Speaker	Ryo Ikeda (The Jikei Univ.), Takayuki Nakagawa (Kyoto Univ.), Makoto Tominaga (Okazaki Inst.)

March 16 (Thu) 10:10-11:40 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

Joint Symposium with the Japanese Society of Clinical Pharmacology and Therapeutics

Topics of Basic and Clinical Pharmacology Novel Mechanisms of Blood Sugar Control and Milestones in Precision Medicine

Chair	Shinichiro Ueda (Univ. of the Ryukyus), Noriyoshi Teramoto (Saga Univ.)
Speaker	Maeda Shiro (Univ. Ryukyus), Oyama Junichi (Saga Univ.), Nomura Masatoshi (Kyushu Univ.), Zhang Quan (Oxford Univ., UK)

March 16 (Thu) 10:10-11:40 Room I (Nagasaki AstopIa SANGO Hall)

Company-Organized Symposium

New developments of therapeutic agents for cancer; cancer driver genes and Immune-Oncology targeted by different therapeutic modalities

Chair	Yasuhiro Funahashi (Eisai Co. Ltd), Takuo Tsukuda (Chugai Pharmaceutical Co., Ltd.)
Speaker	Shiro Shibayama (ONO Pharm Co., Ltd.), Yasuhiro Funahashi (Eisai Co. Ltd), Takuo Tsukuda (Chugai Pharmaceutical Co., Ltd.), Yusuke Ogitani (Daiichi Sankyo Co., Ltd.)

March 15 (Wed) 10:10-11:40 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

The front line of therapeutic agents for chronic pain: drugs for fibromyalgia and new research trends

Chair	Yutaka Kitano (Daiichi Sankyo Co., Ltd.), Yukinori Nagakura (Aomori Univ.)
Speaker	Yukinori Nagakura (Aomori Univ.), Hiroaki Terasawa (Kumamoto Univ.), Yutaka Kitano (Daiichi Sankyo Co., Ltd.), Toshiyuki Asaki (Shionogi & Co., Ltd.)

March 17 (Fri) 14:20-15:50 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

Young Scientists Symposium

Forefront of Research in Nucleic Acid Drugs

Chair	Norifumi Shioda (Gifu Pharm. Univ.), Hiroshi Sugiyama (Kyoto Univ.)
Speaker	Norifumi Shioda (Gifu Pharm. Univ.), Hiroshi Sugiyama (Kyoto Univ.), Takanori Yokota (Tokyo Medical and Dental Univ.)

March 15 (Wed) 10:10-11:40 Room B (Nagasaki Brick Hall International Conference Hall)

Molecular functions of Ca2+-related ion channels in cardiovascular diseases

Chair	Hisao Yamamura (Nagoya City Univ.), Takuro Tomita (Okazaki Inst.)
Speaker	Takuro Tomita (Okazaki Inst.), Yuki Katanosaka (Okayama Univ.), Hisao Yamamura (Nagoya City Univ.)

March 16 (Thu) 16:35-18:05 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

Regulatory Science Symposium

Chair	Toru Kawanishi (NIHS)
Speaker	Shinobu Uzu (PMDA)

March 17 (Fri) 11:45-12:45 Room I (Nagasaki AstopIa SANGO Hall)

Diversity Promotion Symposium

Child-care Oriented Bosses, "Iku-boss" will bring a significant change in Japanese society.
- The key to success in forming a system and working environment for realization of Working-Style Reforms including promotion of active social participation by women.

Chair	Kumiko Ishige (Nihon Univ.)
Speaker	Tetsuya Ando (NPO Fathering Japan)

March 16 (Thu) 11:50-12:50 Room I (Nagasaki AstopIa SANGO Hall)

Symposium

Neural mechanisms underlying retrieval and extinction of fear memory and the development of therapeutics

Chair	Mitsuhiro Yoshioka (Hokkaido Univ.), Satoshi Ozaki (Taisho Pharmaceut Co., Ltd.)
Speaker	Yu Ohmura (Hokkaido Univ.), Makoto Kondo (Osaka Univ.), Mitsuhiko Yamada (NIMH, NCNP)

March 15 (Wed) 10:10-11:40 Room C (Nagasaki Brick Hall Rehearsal Room)

Membrane proteins as drug targets - How can you use structural information for your studies

Chair	Takuya Kobayashi (Kyoto Univ.), Mikio Tanabe (SBRC, IMSS, KEK)
Speaker	Mikio Tanabe (SBRC, IMSS, KEK), Naotaka Hamasaki (Sasebo Public Health Cent.), Takuya Kobayashi (Kyoto Univ., AMED-CREST, PDIS), Takatsugu Hirokawa (AIST, Univ. Tsukuba)

March 15 (Wed) 10:10-11:40 Room D (Nagasaki Brick Hall Meeting Room 1, 2, 3)

New dimension in the regulatory mechanisms of cardiac function aimed at groundbreaking therapeutic strategies for heart failure

Chair	Yuichi Hattori (Univ. Toyama), Yumiko Imai (Akita Univ.)
Speaker	Keiji Kuba (Akita Univ., JST/PRESTO), Yasuhiro Maejima (Tokyo Med. Dent. Univ.), Hideyuki Yamawaki (Kitasato Univ.), Mari Sakai (Univ. of Toyama)

March 15 (Wed) 10:10-11:40 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

Cutting edge of interpretation of desease state and drug discovery research using non-human primates

Chair	Masamitsu Shimazawa (Gifu Pharmaceut. Univ.), Naoto Horai (SNBL DSR)
Speaker	Naoto Horai (SNBL DSR), Hiroyuki Takamatsu (Hamamatsu Pharma Res.), Masamitsu Shimazawa (Gifu Pharmaceut. Univ.)

March 15 (Wed) 10:10-11:40 Room I (Nagasaki AstopIa SANGO Hall)

Signaltrasduction research in cellbellar neurons for drug discovery

Chair	Yasuhito Shirai (Kobe Univ.), Naoaki Saito (Kobe Univ.)
Speaker	Shigeru Tanaka (Hiroshima Univ.), Sho Kakizawa (Kyoto Univ.), Yasuhito Shirai (Kobe Univ.), Keiko Tanaka-Yamamoto (KIST, CFC)

March 15 (Wed) 13:00-14:30 Room C (Nagasaki Brick Hall Rehearsal Room)

Challenge for the treatment of heart failure using known drugs and functional foods

Chair	Motohiro Nishida (Okazaki Inst., NIPS, NINS), Yasushi Fujio (Osaka Univ.)
Speaker	Motohiro Nishida (Okazaki Inst., NIPS NINS), Tatsuya Morimoto (Univ. of Shizuoka), Yasushi Fujio (Osaka Univ.), Kinue Nishioka (PMDA)

March 15 (Wed) 13:00-14:30 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

The functions of endosome / lysosome systems and application for new therapeutic agents

Chair	Takayuki Tsukuba (Nagasaki Univ.)
Speaker	Takayuki Tsukuba (Nagasaki Univ.), Mitsunori Fukuda (Tohoku Univ.), Tomohiko Taguchi (Univ. of Tokyo)

March 15 (Wed) 13:00-14:30 Room H (Nagasaki AstopIa SHINJYU Hall)

Innovative drug development approaches which develop from the molecular identification of transporters

Chair	Yoshikatsu Kanai (Osaka Univ.), Yukio Kato (Kanazawa Univ.)
Speaker	Hiroshi Omote (Okayama Univ.), Yukio Kato (Kanazawa Univ.), Yoshikatsu Kanai (Osaka Univ.)

March 16 (Thu) 10:10-11:40 Room B (Nagasaki Brick Hall International Conference Hall)

Targeting bioactive lipids for development of innovative drugs

Chair	Masataka Majima (Kitasato Univ.), Tomoyuki Furuyashiki (Kobe Univ.)
Speaker	Hideki Amano (Kitasato Univ.), Tomoyuki Furuyashiki (Kobe Univ.), Koh-ichi Yuhki (Asahikawa Med. Univ.), Tomoko Fujita (Kyoto Univ.)

March 16 (Thu) 10:10-11:40 Room C (Nagasaki Brick Hall Rehearsal Room)

Selective Cell Death in the Central Nervous System: Toward Elucidation of the Mechanisms and Establishment of Therapeutics

Chair	Hiroshi Katsuki (Kumamoto Univ.), Hidemi Misawa (Keio Univ.)
Speaker	Kenji Sakamoto (Kitasato Univ.), Hidemi Misawa (Keio Univ.), Hiroshi Katsuki (Kumamoto Univ.)

March 16 (Thu) 10:10-11:40 Room D (Nagasaki Brick Hall Meeting Room 1, 2, 3)

Pleiotropic properties of incretin GLP-1 and its merits and demerits

Chair	Tsuyoshi Shuto (Kumamoto Univ.), Masashi Tanaka (Kyoto Med. Cent.)
Speaker	Nobuaki Egashira (Kyushu Univ. Hosp.), Masashi Tanaka (Clin. Res. Inst., Kyoto Med. Cent), Tsuyoshi Shuto (Kumamoto Univ.)

March 16 (Thu) 10:10-11:40 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

New tide of pharmacological research of iPS cells differentiation and disease specific iPS cell therapeutics

Chair	Naoko Kuzumaki (Hoshi Univ.), Kyoko Miura (Hokkaido Univ.)
Speaker	Naoko Kuzumaki (Hoshi Univ.), Kyoko Miura (Hokkaido Univ.), Hideyuki Okano (Keio Univ.)

March 16 (Thu) 16:35-18:05 Room B (Nagasaki Brick Hall International Conference Hall)

Search for novel physiological / pharmacological actions of n-3 fatty acids and its future prospect

Chair	Shogo Tokuyama (Kobe Gakuin Univ.), Shigenobu Shibata (Waseda Univ.)
Speaker	Shigenobu Shibata (Waseda Univ.), Michio Hashimoto (Shimane Univ.), Kazuo Nakamoto (Kobe Gakuin Univ.)

March 16 (Thu) 16:35-18:05 Room C (Nagasaki Brick Hall Rehearsal Room)

A new evaluation system of autonomic nervous balance in pathophysiological and pharmacological studies

Chair	Nobuyuki Yanagihara (Univ. Occup. & Env. Health), Taizo Kita (Kyushu Nutr. Welf. Univ.)
Speaker	Nobuyuki Yanagihara (Univ. Occup. & Env. Health), Eiichi Tachikawa (Tokyo Univ.), Taizo Kita (Kyushu Nutr. Welf. Univ.)

March 16 (Thu) 16:35-18:05 Room D (Nagasaki Brick Hall Meeting Room 1, 2, 3)

Recent advances in understanding PACAP signaling : New insight into the physiological/pathophysiological roles of PACAP in central and peripheral tissues

Chair	Yukio Ago (Osaka Univ.), Yuki Kambe (Kagoshima Univ.)
Speaker	Tomoya Nakamachi (Univ. Toyama), Yuki Kambe (Kagoshima Univ.), Hirokazu Ohtaki (Showa Univ.), Yukio Ago (Osaka Univ., UCLA)

March 16 (Thu) 16:35-18:05 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

Targeting bioactive lipids for development of innovative drugs

Chair	Chihiro Yabe (Kyoto Pref. Univ.), Koichiro Wada (Shimane Univ.)
Speaker	Misaki Matsumoto (Kyoto Pref. Univ.), Tsuyoshi Mishiro (Shimane Univ.), Kenjiro Matsumoto (Kyoto. Pham. Univ.), Takaomi Kessoku (Yokohama City Univ.)

March 16 (Thu) 16:35-18:05 Room H (Nagasaki AstopIa SHINJYU Hall)

Pharmacological research for creating "First-in-class medicine" originated from Japan

Chair	Hisaharu Yamada (Taisho pharma. Co., Ltd.), Hideo Fukui (Takeda Pharma. Co., Ltd.)
Speaker	Jun Matsukawa (Takeda Pharma. Co., Ltd.), Koji Ueshima (Astellas Pharma Inc.), Koji Matsumoto (Daiichi Sankyo Co., Ltd.)

March 16 (Thu) 16:35-18:05 Room J (Nagasaki Brick Hall Practice Room1)

Novel therapeutic strategies for inherited dieases caused by protein misfolding

Chair	Hirofumi Kai (Kumamoto Univ.), Hideki Nishito (Univ. Miyazaki)
Speaker	Hirofumi Kai (Kumamoto Univ.), Tsukasa Okiyoneda (Kwansei Gakuin Univ.), Hideki Nishito (Univ. Miyazaki)

March 17 (Fri) 10:05-11:35 Room C (Nagasaki Brick Hall Rehearsal Room)

Future pharmacology education: "Problems faced aftre we become a professor"

Chair	Naohiko Anzai (Chiba Univ.), Koichiro Wada (Shimane Univ.)
Speaker	Motoaki Saito (Kochi Univ.), Hitoshi Ando (Kanazawa Univ.), Satoshi Asai (Nihon Univ. Sch. Med.)

March 17 (Fri) 10:05-11:35 Room J (Nagasaki Brick Hall Practice Room1)

Novel strategy for pre-clinical evaluation of chronic pain

Chair	Fusao Kato (Jikei Univ.), Makoto Tsuda (Kyushu Univ.)
Speaker	Makoto Tsuda (Kyushu Univ.), Hidemasa Furue (NIPS), Fusao Kato (Jikei Univ.)

March 17 (Fri) 12:50-14:20 Room B (Nagasaki Brick Hall International Conference Hall)

Molecular understanding of hierarchy and lineage of stem cells toward drug development and regenerative medicine

Chair	Takeshi Takarada (Okayama Univ.), Akira Watanabe (Kyoto Univ.)
Speaker	Kinichi Nakashima (Kyushu Univ.), Takeshi Takarada (Okayama Univ.), Akira Watanabe (Kyoto Univ.)

March 17 (Fri) 12:50-14:20 Room C (Nagasaki Brick Hall Rehearsal Room)

Pharmacology education in nursing: the future of nursing education and the development of human resource

Chair	Toshihiko Yanagita (Univ. Miyazaki), Yoshiro Goshima (Yokohama City Unive.)
Speaker	Shinobu Saito (MEXT), Tomoko Akase (Yokohama City Univ.), Yuka Saeki (Ehime Univ.), Toshihiko Yanagita (Univ. Miyazaki)

March 17 (Fri) 12:50-14:20 Room E (Nagasaki Brick Hall Meeting Room 4,5)

New perspectives of pharmacological drug discovery research using genetically engineered mice

Chair	Kazuhiko Yanai (Tohoku Univ.), Naruhiko Sahara (NIQRST)
Speaker	Naruhiko Sahara (NIQRST), Yuichi Hattori (Univ. Toyama), Takeo Yoshikawa (Tohoku Univ.)

March 17 (Fri) 12:50-14:20 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

CNS diseases are the breakdown of the homeostasis maintainig mechanisms' -the new interpretation leads to new therapeutic strategies-

Chair	Shigeki Moriguchi (Tohoku Univ.), Kaoru Sato (NIHS)
Speaker	Kaoru Sato (NIHS), Shigeki Moriguchi (Tohoku Univ.), Takatoshi Hikida (Kyoto Univ.)

March 17 (Fri) 12:50-14:20 Room I (Nagasaki AstopIa SANGO Hall)

Leading edge research of cell assembly in brain disorder and neural activity regulation

Chair	Minoru Narita (Hoshi Univ.), Akihiro Yamanaka (Nagoya Univ.)
Speaker	Yuji Ikegaya (Univ. Tokyo), Noriko Osumi (Tohoku Univ.), Akihiro Yamanaka (Nagoya Univ.), Minoru Narita (Hoshi Univ.)

March 17 (Fri) 14:20-15:50 Room B (Nagasaki Brick Hall International Conference Hall)

Physiological and Pathophysiological Functions of Redox Signals in CNS

Chair	Sho Kakizawa (Kyoto Univ.), Yoshinori Mikami (Univ. Toho)
Speaker	Norihiro Shibuya (NCNP), Yuki Tatenaka (Tokyo Inst. Tech.), Sho Kakizawa (Kyoto Univ.), Yoshinori Mikami (Univ. Tokyo)

March 17 (Fri) 14:20-15:50 Room C (Nagasaki Brick Hall Rehearsal Room)

Cutting-edge topics in epilepsy research -Seeking for novel antiepileptics-

Chair	Yukihiro Ohno (Osaka Univ. Pharm Sci.), Kumatoshi Ishihara (Hiroshima Intel. Univ.)
Speaker	Schuichi Koizumi (Univ. Yamanashi), Yukihiro Ohno (Osaka Univ. Pharm Sci.), Saeko Ishida (Tokyo Med. Dent. Univ.)

March 17 (Fri) 14:20-15:50 Room D (Nagasaki Brick Hall Meeting Room 1, 2, 3)

New paradigms for research on cardiovascular active substances

Chair	Masato Tsutsui (Univ. Ryukyus), Masanori Yoshizumi (Nara Medical Univ.)
Speaker	Takahiro Horinouchi (Hokkaido Univ.), Masanori Yoshizumi (Nara Medical Univ.), Masato Tsutsui (Univ. Ryukyus), Chihiro Yabe (Kyoto Pref. Univ. Med.)

March 17 (Fri) 14:20-15:50 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

New approach of alternative to animal experiments in Japan

Chair	Yuji Yoshiyama (Kitasato Univ.), Hiroyuki Miyazaki (Japan Bio Products Co., Ltd.)
Speaker	Yuji Yoshiyama (Kitasato Univ.), Hajime Kojima (NIHS), Yasuyuki Sakai (Univ. Tokyo), Koichi Saito (Sumitomo Chemical Co., Ltd.,)

March 17 (Fri) 14:20-15:50 Room I (Nagasaki AstopIa SANGO Hall)

Development of strategy for the therapy of incurable diseases based on their mechanisms and bioactive molecules from Kampo medicines

Chair	Hiroyuki Fukui (Tokushima Univ.), Kinzo Matsumoto (Univ. Toyama)
Speaker	Hironori Fujiwara (Univ. Toyama), Kaori Kubota (Fukuoka Univ.), Suresh Awale (Univ. Toyama), Hiroyuki Fuku i(Tokushima Univ.)

March 17 (Fri) 14:20-15:50 Room J (Nagasaki Brick Hall Practice Room1)

Early Morning Workshop*

* Breakfast included

Perspectives on investigations of chronic dysfunction based on recent novel findings for ion channels

Chair	Jun Yamazaki (Fukuoka Dent. Coll.), Susumu Ohya (Kyoto Pharmaceut. Univ.)
Speaker	Kunitoshi Uchida (Fukuoka Dent. Coll.), Makoto Tsuda (Kyushu Univ.), Susumu Ohya (Kyoto Pharmaceut. Univ.)

March 16 (Thu) 7:50-8:50 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

Frontier of glaucoma research; the latest molecular pathogenesis and strategies

Chair	Schuichi Koizumi (Univ. Yamanashi)
Speaker	Youichi Shinozaki (Univ. Yamanashi), Takayuki Harada (Tokyo Metropol. Inst. Med. Sci.), Masayuki Ohta (KOWA CO., LTD.)

March 16 (Thu) 7:50-8:50 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

Development of antitumor drug screening based on the stress responses to tumor microenvironment

Chair	Shuhei Tomita (Osaka City Univ.), Hideko Nagasawa (Gifu Pharm. Univ.)
Speaker	Masayuki Shiota (Osaka City Univ.), Hideko Nagasawa (Gifu Pharm. Univ.), Yasuhito Shimada (Mie Univ.)

March 16 (Thu) 7:50-8:50 Room H (Nagasaki AstopIa SHINJYU Hall)

Various functions of Shati/Nat8l-Brain, Pain and Metabolism

Chair	Atsumi Nitta(Univ. of Toyama)
Speaker	Atsumi Nitta (Univ. of Toyama), Masahiro Ohsawa (Nagoya City Univ.), Juliane G. Bogner-Strauss (Graz Univ. of Technology)

March 16 (Thu) 7:50-8:50 Room I (Nagasaki AstopIa SANGO Hall)

Drug repositioning targeting for central nerve diseases

Chair	Kazuhiro Tsuruma (Gifu Pharma. Univ.), Masaaki Tagawa (Sumitomo Dainippon Pharma Co., Ltd.)
Speaker	Yuhei Nishimura (Mie Univ.), Hideki Ito (Otsuka Pharma. Co., Ltd.), Masaaki Tagawa (Sumitomo Dainippon Pharma Co., Ltd.)

March 17 (Fri) 7:50-8:50 Room F (Nagasaki AstopIa SHOUKAKU Hall (East))

Paradigm Shift from Genomics to Phenomics-Driven Drug Discovery

Chair	Toshiaki Kume (Kyoto Univ.), Toshio Tanaka (Mie Univ.)
Speaker	Toshio Tanaka (Mie Univ.), Makoto Kobayash (Univ. Tsukuba), Toshiaki Kume (Kyoto Univ.)

March 17 (Fri) 7:50-8:50 Room G (Nagasaki AstopIa SHOUKAKU Hall (West))

How and how closely can we achieve beneficial effects of physical exercise by pharmacotherapy and future drug discovery?

Chair	Licht Miyamoto (Tokushima Univ.)
Speaker:	Yasuki Higaki (Fukuoka Univ.), Naoko Goto-Inoue (Nihon Univ.), Motohiro Nishida (NIPD)

March 17 (Fri) 7:50-8:50 Room H (Nagasaki AstopIa SHINJYU Hall)

The frontier of bionanodiagnostic agent development and its significances

Chair	Hoichi Yorinaka (Kumamoto Univ.), Yasunori Kitamoto (JCHO Sendai Hospital)
Speaker	Yasunori Kitamoto (JCHO Sendai Hospital), Hoichi Yorinaka (Kumamoto Univ.)

March 17 (Fri) 7:50-8:50 Room I (Nagasaki AstopIa SANGO Hall)

Extension Lecture Open to the Public

Keynote Lecture

Chair	Hiroshi Ueda (Nagasaki Univ.)
Speaker	Kenichiro Nakashima (Nagasaki International Univ.)

Special Lecture

Chair	Taku Yamaguchi (Nagasaki International Univ.)
Speaker	Masahiko Funada (Department of Drug Dependence Research, NIMH, NCNP)

March 17 (Fri) 19:00-21:00 Room B (Nagasaki Brick Hall International Conference Hall)

Program

Plenary Lecture

Dynamics of Function and Regulation of the Endoplasmic Reticulum (ER)

Special Lecture

Checkpoint blockade cancer immunotherapy: history and future perspectives

NMDA receptor dysfunction in autism spectrum disorders

Calcium signaling: From in vivo imaging to pathophysiological analyses

Mechanism and biological output of membrane phospholipid diversity

Osteoimmunology and the progress of treatment of bone and joint diseases

Towards the Mysteries of Sleep

Molecular basis of environmental stress response and diseases

The next-generation mouse models of Alzheimer's disease

Special Guest Lecture

Müller glia and retina regeneration

Retinal cell therapy using iPS cells

JPS-ASCEPT Lecture

Targeting binary GABAA receptors : A possible role for zolpidern in stroke and motor recovery

Ebashi Setsuro Award Lecture

Studies on Function and Pathology of Brain Circuits

Encouragement of Young Investigator Award Lecture

Analysis of astrocytic function using Ca2+ imaging

Functional dynamics of brain cell networks in health and disease

Elucidation of intracellular signaling mechanism mediated by dopamine D2 receptor

Educational Seminar

Signaling molecules: hydrogen sulfide (H2S) and polysulfides (H2Sn)

L-DOPA neurotransmitter hypothesis

JPS Satellite Symposium

Efficient Drug Development by using State-of-the-art Imaging Technologies

Annual Meeting Symposium

New perspective of pharmacology education: to question the propriety of pharmacology educator license

Academic Drug Discovery

Pharmacological research benefits returnable for inauguration

New Challenge of Cancer Therapy - Cutting edge of multidisciplinary teams harmonized with basic and clinic -

Frontiers in drug development targeting DAMPs with dual Yin and Yang nature

Healthy Longevity to learn from Oral Brain Science

Leading-edge studies for diabetic nephropathy

Annual Meeting Special Symposium

Current and future for the therapies of retinal diseases - Basic and clinical studies of retinal regeneration, iPS and retinal neovascularization -

Annual Meeting Company-Sponsored Symposium

Pharmacological research of traditional Japanese medicine (Kampo medicine) in top journals in science - Possible role of rikkunshito as an endogenous ghrelin enhancer -

Annual Meeting Nano Symposium

Pharmacology of functional foods

Joint Symposium with the Japanese Medical Science Federation

Drug discovery for mitochondrial diseases - Turning point in a new era

Joint Symposium with the Physiological Society of Japan

Advanced molecular biological research in pain, itch and dysesthesia

Joint Symposium with the Japanese Society of Clinical Pharmacology and Therapeutics

Topics of Basic and Clinical Pharmacology Novel Mechanisms of Blood Sugar Control and Milestones in Precision Medicine

Company-Organized Symposium

New developments of therapeutic agents for cancer; cancer driver genes and Immune-Oncology targeted by different therapeutic modalities

The front line of therapeutic agents for chronic pain: drugs for fibromyalgia and new research trends

Young Scientists Symposium

Forefront of Research in Nucleic Acid Drugs

Molecular functions of Ca2+-related ion channels in cardiovascular diseases

Regulatory Science Symposium

Diversity Promotion Symposium

Child-care Oriented Bosses, "Iku-boss" will bring a significant change in Japanese society. - The key to success in forming a system and working environment for realization of Working-Style Reforms including promotion of active social participation by women.

Symposium

Neural mechanisms underlying retrieval and extinction of fear memory and the development of therapeutics

Membrane proteins as drug targets - How can you use structural information for your studies

New dimension in the regulatory mechanisms of cardiac function aimed at groundbreaking therapeutic strategies for heart failure

Cutting edge of interpretation of desease state and drug discovery research using non-human primates

Signaltrasduction research in cellbellar neurons for drug discovery

Challenge for the treatment of heart failure using known drugs and functional foods

The functions of endosome / lysosome systems and application for new therapeutic agents

Innovative drug development approaches which develop from the molecular identification of transporters

Targeting bioactive lipids for development of innovative drugs

Selective Cell Death in the Central Nervous System: Toward Elucidation of the Mechanisms and Establishment of Therapeutics

Pleiotropic properties of incretin GLP-1 and its merits and demerits

New tide of pharmacological research of iPS cells differentiation and disease specific iPS cell therapeutics

Search for novel physiological / pharmacological actions of n-3 fatty acids and its future prospect

A new evaluation system of autonomic nervous balance in pathophysiological and pharmacological studies

Recent advances in understanding PACAP signaling : New insight into the physiological/pathophysiological roles of PACAP in central and peripheral tissues

Targeting bioactive lipids for development of innovative drugs

Pharmacological research for creating "First-in-class medicine" originated from Japan

Novel therapeutic strategies for inherited dieases caused by protein misfolding

Future pharmacology education: "Problems faced aftre we become a professor"

Novel strategy for pre-clinical evaluation of chronic pain

Molecular understanding of hierarchy and lineage of stem cells toward drug development and regenerative medicine

Pharmacology education in nursing: the future of nursing education and the development of human resource

Targeting binary GABA_A receptors : A possible role for zolpidern in stroke and motor recovery

Analysis of astrocytic function using Ca²⁺ imaging

Elucidation of intracellular signaling mechanism mediated by dopamine D₂ receptor

Signaling molecules: hydrogen sulfide (H₂S) and polysulfides (H₂S_n)

Child-care Oriented Bosses, "Iku-boss" will bring a significant change in Japanese society.
- The key to success in forming a system and working environment for realization of Working-Style Reforms including promotion of active social participation by women.